Project description
Reawakening the immune system to fight cancer
Tumours often deploy a variety of immune evasion strategies to escape detection and destruction by the body’s immune system. These include expression of immune checkpoint molecules to inhibit T cell activity, the expression of immunosuppressive cytokines, as well as the recruitment of regulatory T cells to dampen immune responses. Therefore, reawakening the immune system is a promising cancer treatment strategy. The EIC-funded NTX1088 project brings to the clinic an innovative antibody targeting the human poliovirus receptor (PVR) which is a key regulator of immune activation and is overexpressed in various cancer cells. The anti-PVR antibody works to restore immune cell function by activating T cells and natural killer cells against cancer.
Objective
Nectin Therapeutics (NectinTx) is a venture-backed company with a top-notch team focused on innovative therapeutic options for cancer patients. To address the limitations of available therapies, the company has developed a diverse pipeline of antibodies that overcome immune inhibitory pathways deployed by the tumours. NTX1088 is a monoclonal antibody that binds human poliovirus receptor (PVR) and activates patients immune system to fight cancer through a triple mechanism of action never demonstrated before. A comprehensive preclinical dataset was generated to show the robust antitumor activity of NTX1088 in vitro and in vivo. Following IND approval and strong backing from key opinion leaders, Phase I clinical trial has commenced, aimed to enrol patients with solid tumours. The project will accelerate the clinical development of NTX1088 towards a novel therapy on the 80 billion immune-oncology drug market, resulting in better outcomes for patients and reduced societal and economic burden associated with cancer.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
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Keywords
Programme(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Funding Scheme
HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended FinanceCoordinator
91390 JERUSALEM
Israel
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.