Objective
The chromophores of photo-responsive proteins (PRPs) are increasingly exploited in science and technology from time and spatially resolved studies of neural signaling to the engineering of fully synthetic molecular devices. This justifies the increasing need for interdisciplinary studies aiming at controlling the chromophore function and achieving novel applications. In this doctoral network we will combine design, preparation and theory of PRP chromophores operating as rotary molecular-level devices with the novel tool of time-resolved photoemission spectroscopy (TRPES) to unravel basic principles of their rotary function.
The most prominent PRPs, e.g. retinal proteins, the green fluorescent protein or xanthopsin all convert the photon energy into rotary motion by leveraging efficient ultrafast double-bond isomerizations. There is a consensus that such energy conversion is mediated by conical intersections (CIs) between ground and excited state potential energy surfaces. TRPES is a novel method, emerging at the interface of ultrafast physics and chemistry, capable of imaging the dynamics through CIs, thus providing a unique view on the
photon-to-nuclear-rotation transduction process. More specifically, novel TRPES tools developed within the network will be employed to study devices based on oxindoles and oxipyrroles, mimicking the green-fluorescent protein chromophores, and on cinnamic ester derivatives, mimicking the chromophores of xanthopsins. We will investigate and learn to control these systems studying selected sets of chemical substitutions and environmental effects.
The development of an effective research protocol focused on the combination of novel syntheses, TRPES and interpretative state-ofthe-art quantum chemical methods, will provide a cutting-edge interdisciplinary training arena for talented doctoral students and will be complemented by a modern soft-skill learning program and intense knowledge exchange between science and industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesphysical sciencesopticsspectroscopy
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Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
12489 Berlin
Germany
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Participants (7)
75794 Paris
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56126 Pisa
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80539 Munchen
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751 05 Uppsala
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53100 Siena
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97070 Wuerzburg
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166 28 Praha
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Partners (9)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
14109 Berlin
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
37077 Göttingen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
65232 Taunusstein
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
06600 Antibes
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
33600 Pessac
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
14195 Berlin
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
67081 Strasbourg
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
76131 Karlsruhe
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
WC1E 6BT London
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