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Computational and Experimental Enzyme Engineering for New Polymers

Project description

Enzymes for a sustainable polymer industry

Many items we use in everyday life are made of polymeric materials such as plastics and are of fossil origin. However, we need to redesign the polymer chain using sustainable raw materials, processes, and recycling. Enzymes offer eco-friendly solutions for this shift but face challenges like high costs, low stability, and inefficiency. With the support of the Marie Skłodowska-Curie Actions programme, the COMENZE project aims to address these issues by integrating computational and experimental methods to enhance enzyme discovery and engineering. By developing optimised enzymes and bio-based polymers, COMENZE seeks to foster a sustainable polymer industry and train researchers to drive innovations in the field.

Objective

Polymeric materials are ubiquitous in our daily lives but they have a predominantly fossil origin, with low degradability at their end-of-
life. Transitioning to a circular polymer economy requires a rethinking of the entire value chain, from the raw materials, tools, and processes used to polymer design degradation and recycling. Enzymes are eco-friendly and sustainable tools that tackle many industrial applications. However, biocatalysis in the polymer field remains mostly unexplored due to i) enzymes high cost and low stability under reaction conditions, ii) enzymes inefficiency in converting bio-based monomers into cost-effective building blocks, and iii) lack of knowledge in key enzyme-polymer interactions that can control the final polymer performance and degradability features. Computational tools have shown immense power to revolutionize the field of enzyme engineering in a time and cost effective way. However, there is currently a clear lack of researchers combining computational and experimental skills, capable of determining future directions for the optimization of biocatalytic processes for the sustainable molecular design of polymers.

To foster the transition to a bio-based polymer industry, COMENZE aims to develop enzymatic strategies for improving the eco-design and development of future sustainable polymers. This will be achieved by combining cutting-edge computational and experimental approaches for enzyme discovery and engineering through in-silico modeling, simulation, and translation of results into wet labs to validate enzymatic reactions. COMENZE will train the next generation of researchers by equipping 10 DCs with the skills to revolutionize the polymer circularity by delivering new optimized enzymes and bioprocesses, newly identified bio-based building blocks, and functionalized polymers with innovative bio-upcycling and biodegradation end-of-life options.

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

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(opens in new window) HORIZON-MSCA-2023-DN-01

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Coordinator

UNIVERSIDADE NOVA DE LISBOA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 243 403,20
Address
CAMPUS DE CAMPOLIDE
1099 085 Lisboa
Portugal

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Activity type
Higher or Secondary Education Establishments
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Total cost

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Participants (9)

Partners (3)

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