Project description
Pioneering 3-in-1 crystallisation process for sustainable drug manufacturing
Downstream processing, a key step in the separation and purification of biopharmaceuticals, faces significant challenges as unit operations involved have low throughput, poor scalability, high energy consumption, and equipment and materials are expensive. In addition, the resulting liquid formulations are often unstable and degrade easily. With the support of the Marie Skłodowska-Curie Actions programme, the PROCRYSTAL project aims to enable crystallisation as a simple, sustainable, cost-efficient and scalable alternative to current downstream processing techniques and liquid formulations. To do so, it will train doctoral candidates in the underlying phenomena, from the molecular scale to process scale, and in advanced experimental and modelling techniques specific to crystallisation technology.
Objective
"Downstream processing (DSP) of biopharmaceuticals is dominated by chromatographic steps which suffer from low throughput, poor scalability and elevated energy consumption, as well as high equipment and materials costs. To this is added the low stability and high degradability of liquid formulations. The training program ""Crystallisation towards efficient and sustainable biomanufacturing"" (PROCRYSTAL) vision is that of crystallisation as a simple, sustainable, cost-efficient and scalable alternative to current DSP techniques and liquid formulations, once it allows to separate, purify and stabilise in a single step. Nevertheless, integrated training to exploit biocrystallisation full potential is currently not available, only fragmented research activities. Within this training program, 13 Doctoral candidates (DCs) are expected to go beyond current practise to respond to the near future biopharma manufacturing needs. And only possible leveraged by the expertise conveyed in this consortium on biomolecules crystallisation, biochemistry, chemical and process engineering as well as advanced modelling. The PROCRYSTAL training program for the DCs has been framed with special attention to fundamental understanding of the underlying phenomena, from the molecular scale to process scale, and advanced experimental and modelling techniques specific to crystallisation technology. The DCs will acquire a wide range of subject specific and general transferable skills, in an interdisciplinary and inter-sectoral environment and by multinational collaboration which enhances the early-career DCs long term employability and competitiveness.
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Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4704 553 Braga
Portugal
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Participants (8)
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3000 LEUVEN
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1756 Sofia
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75794 PARIS
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1050 BRUSSEL
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28006 MADRID
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1111 BUDAPEST
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1348 OTTIGNIES-LOUVAIN-LA-NEUVE
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2340 Beerse
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Partners (8)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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20158 MILANO
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1099 085 Lisboa
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94250 Gentilly
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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CB8 7SQ Newmarket
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13284 Marseille
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18071 GRANADA
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91000 Évry-Courcouronnes, Paris Region
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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SW7 2AZ London
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