Objective
The intestinal tract is inhabited by a large and diverse community of microorganisms, collectively referred to as the microbiota. When stably maintained, the microbiota provides important benefits to its host. However, disturbance of the microbiota-host relationship can perturb homeostasis and drive chronic intestinal inflammation, a cardinal feature of an array of diseases including Inflammatory Bowel Disease.
While many factors regulate microbiota composition and function, numerous studies have revealed a central role for diet in modulating this complex community and, consequently, its impacts on host health. My research group has investigated how microbiota is impacted by components of processed foods, particularly emulsifiers and purified fibres. We have reported that these substances have marked modulatory potential on the microbiota in a way that broadly impacts host physiology. However, the extent of such modulations is not uniform but rather subject to high levels of inter-individual and microbiota-dependent variations. These observations have led to the central hypothesis driving the InterBiome proposal, namely that the intestinal microbiota is a central nexus in driving inter-individual variations in the extent to which various dietary factors impact health.
We will investigate this hypothesis via a combination of integrated experimental approaches, including patient-based prospective studies, in vitro microbiota modelling and gnotobiotic approaches. Results of these studies will define mechanisms by which the intestinal microbiota drives inter-individual variation in responses to select food additives in a way that promotes or degrades intestinal health. The InterBiome project will open novel avenues of microbiota research, paving the way for microbiota-based personalized medicine and dietary management.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences nutrition
- natural sciences biological sciences microbiology
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.