Objective
We are in a constant and ever evolving battle with viruses. Our only defence are vaccines or antivirals. Both are typically developed in response to viral outbreaks meaning that any defence we mount is reactive and not proactive. Despite the clear need for improved interventions against viruses, there is a lack of innovation, novel materials, targeted approaches and systematic studies. Building on my experience in extracellular antivirals, I have recently identified a series of star polymer materials that display low toxicity (both in vitro and in vivo), can be produced cheaply at scale, and are potent broad-spectrum virucides (in vitro and in vivo). This seminal finding represents a significant leap forward in the development of biocompatible virucides, and with investment in their development, they will be ready for future viral outbreaks.
POLYVIR will push the boundaries and expand the synthetic space of these biocompatible virucides by implementing high-throughput, oxygen-tolerant polymerisation, combined with liquid-handling robots, to create libraries of polymer virucides. To screen this unprecedented number of antiviral samples, high- throughput, cell-free, virucidal assays and techniques will be developed and then implemented, enabling screening of a range of structure-property relationships and expanding the scope and breadth of these virucides. Expansion to include glycol-polymers will allow for a truly pan-viral biocompatible virucide to be produced. To prevent animal pandemics, we will also focus on improving their activity window by enabling activity in high-protein and/or low-temperature environments. Our potent virucidal polymers will be applied as coatings to engineer surface properties of a range of materials to create long-lasting broad-spectrum antiviral surfaces and textiles. This project will consolidate my research at the forefront of extracellular antivirals globally and produce the next generation of scientists in this globally relevant fie
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences public health epidemiology pandemics
- natural sciences chemical sciences polymer sciences
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.