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The GRASSHOPPER network: Jumping forward from preclinical development of pediatric cancer drugs to clinical implementation

Project description

Advancing cancer treatments for children

Each year, 16 000 children in Europe are diagnosed with cancer, and nearly 2 000 die from the disease. While progress is being made in developing therapies, many treatments fail to reach the clinic due to gaps in the transition from lab research to patient care. In addition, access to cutting-edge treatments varies drastically between countries. Supported by the Marie Skłodowska-Curie Actions programme, the GRASSHOPPER project will create a multidisciplinary network across Europe and beyond. With 17 stakeholders from 16 countries, it will focus on preclinical validation of novel therapies, repurposing existing drugs and improving clinical trials. The goal is to accelerate the delivery of effective treatments and foster international collaboration for future cancer research.

Objective

Every year 16.000 children in Europe are diagnosed with cancer, and 2000 children (approximately 70 school classes) die from this illness. New therapeutic solutions are advancing rapidly however the optimization and implementation into clinical trials accessible for these children is lacking behind. New therapeutic interventions often don’t make it through the valley of death between preclinical development and clinical implementation. In addition, the accessibility between countries of new treatments varies largely. Therefore, the GRASSHOPPER consortium aims to create a multidisciplinary network of stakeholders in pediatric cancer development to boost implementation of new therapeutic interventions for children with cancer across Europe and beyond. GRASSHOPPER consists of 10 beneficiaries and 7 associated partners located in 16 countries: 6 academic European Comprehensive Childhood Cancer Centers (CCCC’s) and 3 non-European CCCC’s, 5 non-academic national leading Childhood Cancer Centers, 2 leading pharmaceutical companies and 1 non-for-profit drug developer. The consortium has 4 objectives: identification and preclinical validation of new immune interventions (1) and new molecular interventions (2), stimulating repurposing of available therapeutic interventions (3) and improving clinical validation of high potential therapeutic interventions for pediatric cancer (4). These objectives will be achieved by intersectoral secondments between the various beneficiaries and partners. The consortium expects that these objectives will lead to a strong international and multidisciplinary network, exchange of knowledge and expertise between sectors and countries and lead to highly skilled researchers, trained in pediatric and transferable skills, and with a large network for future career perspectives, that will jump over the valley of death and accelerate new treatments.

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Topic(s)

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HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges

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Call for proposal

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(opens in new window) HORIZON-MSCA-2023-SE-01

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Coordinator

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 404 800,00
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (9)

Partners (7)

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