Project description
Continuous, real-time analyte ‘fingerprinting’ using magneto-plasmonic nanocarriers and AI
Gene therapy – changing or replacing faulty genes to prevent, treat or cure diseases – has shown tremendous promise in many areas but exploiting its full potential has faced challenges. The EU-funded GeneH project aims to create an excellence hub in gene therapy focused on life-threatening or chronically debilitating diseases that are considered incurable. The project’s core academic partners in Portugal and Slovenia have successful partnerships with industry, hospitals, policymakers, ecosystem/innovation supporters and patient associations. Through a cross-sectoral, multidimensional approach, the team will tackle challenges in research and development, translation, investment, regulatory and ethical issues while also providing educational and training programmes and engaging with society. Ultimately, GeneH plans to pave the way to clinical trials of innovative gene therapies.
Objective
Thousands of chemical substances are currently produced by humans for various purposes with a substantial portion leaking into the environment. The European Commission has already defined the following two priorities: protecting our biodiversity and ecosystems, and reducing air, water and soil pollution within the environment and oceans actions included in the recently approved European Green Deal programme.
WATERsense aims at developing a new concept and respective prototype for universal vibrational spectroscopy-based analyte fingerprinting that is performed in continuous manner and enables sensitive monitoring of analytes. To attain this main objective we will fabricate magneto-plasmonic nano-objects that will carry the analytes to be detected. These nanocarriers will flow through a micro/nanofluidic chip system where they will be trapped, docked and subsequently optically probed by Raman spectroscopy. WATERsense will target the following novel approaches: (i) Molecular Trapping: Controlled analyte (pollutant molecule) loading within the nanocarriers. (ii) Tracking and Transport: Manipulation of a single nanoparticle-carrier in a nano-sized fluidic chamber. (iii) Detection: Ultrasensitive analyte detection up to 6 orders of magnitude below the required concentration range. (iv) Analysis: Quantitative, extremely fast and continuous pollution detection and real-time analysis based on molecular fingerprinting using machine learning algorithms trained on large datasets.
WATERsense technology will enable the real-time tracking of concentration changes of a set of important pollutants that represent a danger for humankind and environment, revolutionising the field of environmental protection.
In the long run, the WATERsense sensing concept can also be extended to sampling in the food industry, reagent sampling in the pharmaceutical branch, detection of biomarkers for molecular diagnostics and examination of fundamental processes in hydrology, geology and biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesearth and related environmental scienceshydrology
- natural sciencesearth and related environmental sciencesenvironmental sciencespollution
- natural sciencesbiological sciencesecologyecosystems
- natural sciencesearth and related environmental sciencesgeology
- natural sciencesphysical sciencesopticsspectroscopy
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Keywords
Programme(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Funding Scheme
HORIZON-EIC - HORIZON EIC GrantsCoordinator
08007 Barcelona
Spain