Project description
Continuous, real-time analyte ‘fingerprinting’ using magneto-plasmonic nanocarriers and AI
Gene therapy – changing or replacing faulty genes to prevent, treat or cure diseases – has shown tremendous promise in many areas but exploiting its full potential has faced challenges. The EU-funded GeneH project aims to create an excellence hub in gene therapy focused on life-threatening or chronically debilitating diseases that are considered incurable. The project’s core academic partners in Portugal and Slovenia have successful partnerships with industry, hospitals, policymakers, ecosystem/innovation supporters and patient associations. Through a cross-sectoral, multidimensional approach, the team will tackle challenges in research and development, translation, investment, regulatory and ethical issues while also providing educational and training programmes and engaging with society. Ultimately, GeneH plans to pave the way to clinical trials of innovative gene therapies.
Objective
Thousands of chemical substances are currently produced by humans for various purposes with a substantial portion leaking into the environment. The European Commission has already defined the following two priorities: protecting our biodiversity and ecosystems, and reducing air, water and soil pollution within the environment and oceans actions included in the recently approved European Green Deal programme.
WATERsense aims at developing a new concept and respective prototype for universal vibrational spectroscopy-based analyte fingerprinting that is performed in continuous manner and enables sensitive monitoring of analytes. To attain this main objective we will fabricate magneto-plasmonic nano-objects that will carry the analytes to be detected. These nanocarriers will flow through a micro/nanofluidic chip system where they will be trapped, docked and subsequently optically probed by Raman spectroscopy. WATERsense will target the following novel approaches: (i) Molecular Trapping: Controlled analyte (pollutant molecule) loading within the nanocarriers. (ii) Tracking and Transport: Manipulation of a single nanoparticle-carrier in a nano-sized fluidic chamber. (iii) Detection: Ultrasensitive analyte detection up to 6 orders of magnitude below the required concentration range. (iv) Analysis: Quantitative, extremely fast and continuous pollution detection and real-time analysis based on molecular fingerprinting using machine learning algorithms trained on large datasets.
WATERsense technology will enable the real-time tracking of concentration changes of a set of important pollutants that represent a danger for humankind and environment, revolutionising the field of environmental protection.
In the long run, the WATERsense sensing concept can also be extended to sampling in the food industry, reagent sampling in the pharmaceutical branch, detection of biomarkers for molecular diagnostics and examination of fundamental processes in hydrology, geology and biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences hydrology
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences earth and related environmental sciences geology
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2024-PATHFINDEROPEN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08007 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.