Project description
Advanced hybrid implants for hip arthroplasty
Aseptic loosening is a leading cause of hip arthroplasty revision surgeries. Titanium (Ti) alloys exhibit high strength but are associated with stress shielding and bioinertness, while magnesium (Mg) alloys offer excellent biocompatibility but show rapid degradation. Combining Ti and Mg in composites can enhance bone repair, although galvanic corrosion between these two dissimilar metals in body fluid is a major challenge. Supported by the Marie Skłodowska-Curie Actions programme, the HITECH project will develop osteoblast-type cell-loaded hybrid implants for hip arthroplasty with a bioactive magnesium oxide (MgO) coating at the Ti-Mg interface. It will advance fabrication through additive manufacturing, casting and bioactive coatings, address galvanic corrosion through surface modification, assess mechanical behaviours in vitro, and improve biocompatibility by integrating osteoblast-type cells.
Objective
Aseptic loosening, responsible for about 55.2% of hip arthroplasty revision surgeries globally, is primarily caused by stress shielding. While biomedical titanium (Ti) alloys offer high specific strength, they are bioinert and contribute to stress shielding. Conversely, magnesium (Mg) alloys, with their lower Youngs modulus, reduce stress shielding and offer better biocompatibility, although they suffer from issues of uncontrolled degradation. Therefore, combining Ti and Mg in composites holds promise for improving bone repair by harnessing the benefits of both materials.
However, the contact between dissimilar metals (Ti and Mg) in body fluids can cause galvanic corrosion, which accelerates the degradation of Ti-Mg hybrid implants. To address this issue, the HITECH project proposes using a bioactive magnesium oxide (MgO) coating at the Ti-Mg interface. The project aims to advance hybrid implants for hip arthroplasty by achieving four key objectives: (1) Developing a fabrication process that incorporates additive manufacturing, bioactive coatings, acid etching, and capillary-assisted pressure-less infiltration techniques; (2) Controlling galvanic corrosion through surface modification of Ti; (3) Evaluating mechanical behaviors under in vitro corrosion conditions; and (4) Enhancing in vitro biocompatibility by integrating osteoblast-type cells.
The project seeks to merge Dr. Duttas extensive material knowledge and experience, combined with the biomedical expertise, diverse backgrounds, and broad collaboration networks of the supervisors, supported by the state-of-the-art infrastructure at Helmholtz Zentrum Hereon. This interdisciplinary research spanning metallurgy, advanced coatings, bio-laboratory work, and modeling will broaden Dr. Duttas expertise and significantly enhance career opportunities. Helmholtz Zentrum Hereon will benefit from the researchers contributions to its research initiatives and industrial applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering composites
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- engineering and technology materials engineering coating and films
- medical and health sciences medical biotechnology implants
- engineering and technology materials engineering metallurgy
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
21502 GEESTHACHT
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.