Project description
Understanding risk after aortic surgery
Even after life-saving graft surgery, patients with genetically triggered thoracic aortic aneurysms (TAA) remain at risk. New complications, such as dissections or additional aneurysms, may develop in the sections of the aorta left untreated. Supported by the Marie Skłodowska-Curie Actions programme, the Aortic Biomechanics project is investigating why. Using advanced cardiac imaging and computer modelling, researchers are exploring how grafts interact with native tissue. By integrating biomechanical data with genetic factors, the study aims to pinpoint which patients are most at risk. A key goal is to develop grafts tailored to individual needs, potentially reducing future complications. The research represents a step towards more personalised, precise care for TAA patients and could reshape post-surgical outcomes.
Objective
This proposal aims to investigate the biomechanical mechanisms driving adverse aortic remodeling in patients with genetically triggered thoracic aortic aneurysms (TAA) following prosthetic graft surgery. The study seeks to identify critical features of both native aortic tissue and prosthetic grafts that contribute to the increased risk of distal aortic complications, such as dissection and aneurysm.
These objectives will be achieved by:
1. Advanced imaging and computational modeling: We will employ state-of-the-art cardiac magnetic resonance imaging (CMR) and 4D flow MRI to gather detailed pre- and post-operative data. This data will inform fluid-structure interaction (FSI) models to simulate the complex biomechanical interactions between grafts and the native aorta, providing insights that extend beyond traditional approaches.
2. Biomechanical and genetic integration: By analyzing the stiffness and wall shear stress (WSS) of the aorta before and after grafting, and correlating these changes with clinical outcomes, the study bridges the gap between genetic predispositions and biomechanical responses. This approach will also explore the role of hemodynamic forces in driving the progression of TAA, helping to identify patients at higher risk for adverse outcomes.
3. Tailored graft design: The proposal’s innovative approach includes the development of grafts with compliance tailored to individual patient characteristics. These tailored grafts, designed using FSI simulations, have the potential to reduce the risk of adverse remodeling, setting this study apart from others that use standard graft materials.
This proposal advances personalized medicine by integrating genetic and biomechanical insights to enhance patient-specific treatment of thoracic aortic aneurysms. It aligns with MSCA’s goals by fostering interdisciplinary collaboration, driving innovation in healthcare, and translating research into tangible societal benefits.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine surgery
- natural sciences biological sciences biophysics
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20133 Milano
Italy
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