Objective
"Cancer remains a tough challenge, largely because 80% of cancer-driving proteins are considered “undruggable” meaning impossible to target with conventional therapies. Nano-LYTAC project brings together experts in nanomedicine, pharmaceutical technology, and nanotoxicology to answer the burning question: Does complete cancer eradication still remain as an elusive dream? By combining 2 cutting-edge technologies: “Smart Nanotechnology” and “Targeted Protein Degraders (TPDs)”, this project fulfills the goals of Europe’s Beating Cancer Plan by tackling these undruggable proteins. TPDs were created using Nobel Prize-winning bioorthogonal chemistry. Among these, LYTACs (Lysosomal Targeting Chimeras), with their ability to transport intracellular/extracellular cancer-driving protein for selective degradation in the lysosomes, abrogate the cancer pathology. However, despite their promise, LYTACs haven’t made it to clinical use yet, owing to challenges like limited molecule diversity, poor tumor penetration, low bioavailability, and metabolic instability. To transform LYTACs into clinically viable cancer therapies, and to overcome the aforementioned drawbacks, this project will use novel nanotechnological approach to enable enhanced tumor penetration, selectivity, protection, and controlled released of the LYTACs in tumor microenvironment. Moreover, for the first time, I will design new LYTAC molecules specifically targeting folate receptors that are overexpressed on many types of cancers (e.g.: breast cancers, lung cancer, ovarian cancers). At CATRIN, under the guidance of Prof. Kateřina Poláková, an expert in nanomedicine and their subcellular trafficking, and nanotoxicology, I will develop ""Smart Nano-LYTACs"" with the preclinical proof of their potential. This multidisciplinary project will also enhance my skills in nanotherapeutics and cancer biology, helping me to work towards my long-term goal of establishing my own research group focused on advanced cancer therapies."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- engineering and technologynanotechnology
- medical and health sciencesmedical biotechnologynanomedicine
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicinepathology
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Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
771 47 Olomouc
Czechia