Project description
Translational research on chronic neurological disorders
Autism spectrum disorder and multiple sclerosis are characterised by complex symptoms with unclear underlying mechanisms. Despite a shift in healthcare towards interconnected views of health, biomedical research often uses reductionist approaches, failing to address patient-relevant outcomes and complexities adequately. Supported by the Marie Skłodowska-Curie Actions programme, the TRANSCEND project aims to enhance translational research in complex and chronic neurological conditions. By adopting a networked approach, it seeks to improve the understanding of research from bench to bedside. This is vital as traditional reductionist methods have been largely exhausted. The project also aims to provide interdisciplinary training, focusing on improving the applicability of animal models, prioritising patient outcomes, reevaluating disease categories, and rethinking theragnostic strategies.
Objective
TRANSCEND brings together expertise in biomedical, computational, behavioural, clinical, epidemiological and philosophical
research to advance translational research in medicine. TRANSCEND aims to add to the chronological and epistemic order of research from bench to bedside to practice with a more networked-based understanding of translation. This is particularly important in translational research on complex and chronic neurological conditions where the few low-hanging fruits of reductionist approaches seem to have been picked.
TRANSCEND involves nine interlinked laboratories from clinical, biomedical, metamethodological, and philosophical sub-projects, which focus on autism spectrum disorder and multiple sclerosis. These conditions are characterised by an interconnected set of physical, cognitive and psychological symptoms, and unknown underlying disease mechanisms. While healthcare has been moving away from a purely single-cause view of medicine towards interconnected concepts of positive health, such a more complicated and nuanced notion of health and dis/ability is unintegrated within biomedical research. Most research designs are not well-suited to consider patient-relevant outcomes, the biological and social complexity of these conditions, and their implications in real-world healthcare settings, because their epistemology is oriented towards purification and reduction concerning research questions, disease models, and experiments.
TRANSCEND proposes an integrative approach to translational research that embraces instead of reduces the complexity and diversity of the biological, clinical and social manifestations of the diagnoses. It will provide an innovative, interdisciplinary training along four research objectives to overcome key limitations of translational research on complex, chronic conditions: (1) making animal models more translational; (2) focusing on patient outcomes and scoping “disease” categories; (3) rethinking theragnostic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8000 Aarhus C
Denmark
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Participants (10)
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0313 Oslo
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4099-002 Porto
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1165 KOBENHAVN
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3000 Leuven
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6525 XZ Nijmegen
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1081 HV Amsterdam
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33615 Bielefeld
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33607 PESSAC CEDEX
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3584 CX Utrecht
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20132 Milano
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Partners (11)
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53123 Bonn
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1040 Bruxelles / Brussel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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8092 Zuerich
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4123 Allschwil
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6511 TM Nijmegen
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1032 LS Amsterdam
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2252 CN Voorschoten
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1081 HV Amsterdam
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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75013 Paris
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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3584 CS Utrecht
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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20132 Milano
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.