Objective
The National Brain Tumor Society of America stated that glioblastoma is one of the most complex, deadly, and treatment-resistant cancers with an average length of survival of 8 months. Surgery is the primary form of treatment, and some drugs are approved for treatment, however, none of these treatments have significantly extended patient lives beyond extra months. Recurrence following surgery is a major problem and is often the ultimate cause of death. Accordingly, our specific aim is to target glioma cells with gas- Metal-Organic Polyhedra (MOP) conjugates after/before surgery removal of the tumor in in vivo mice models of glioblastoma cancer. Therapeutic gases (i.e. CO and NO) will be absorbed in the MOP cavity, while the surface will be functionalized for tumor targeting. The system will be dispersed in a biodegradable hydrogel, that will assist in the progressive delivery into the tumor cells once it is injected into the brain. Hydrogel will be tested as a gas-MOP system dispersion medium and as a conjugated treatment including already-known chemotherapeutic drugs for glioma (i.e. Temozolomide, Carmustine or Bevacizumab). The ultimate goal of the project is to create a patch made of bioresorbable hydrogel containing drug and MOP-gas conjugates for local release in glioblastoma tumoral cells. This dual system will be specifically and locally delivered in tumor cells by functionalization of MOP linkers to target and attach to the tumor. To the best of our knowledge, this is the first time that (i) Metal-Organic Polyhedras (MOPs) are used in cancer therapy as carrier systems and (ii) a combined treatment gas/drug is applied for glioblastomas to eliminate or reduce the tumor before/after surgery removal. This proposal achieves the aims of the European Research Area and is highly relevant to the Marie Curie Programme and to long-term career development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2024-TALENTS-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1099 085 Lisboa
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.