Project description
Engineering next-generation injectable implants
Injectable implants are used in medicine and aesthetics, from treating urinary incontinence to correcting wrinkles. However, current materials are recognised as foreign by the immune system and trigger a chronic inflammatory response associated with pain, tissue damage and reduced implant longevity. The ERC-funded CAMFLAKES project introduces a fully biological, human-derived injectable implant designed to eliminate this foreign body reaction. This novel implant has been designed to form living tissue that integrates naturally and persists long-term. The technology will initially be tested in preclinical models and validated for further commercial applications.
Objective
Injectable implants are widely used to treat numerous medical conditions, such as stress urinary incontinence, which affects 1 in 5 women. They also represent a large fraction of aesthetic procedures (e.g. wrinkle correction). The efficacy of current products is hampered by the fact that they create a chronic inflammatory response called the Foreign Body Reaction (FBR). As a result, implants have limited durability, requiring repeated procedures, and are associated with complications such as chronic pain and tissue erosion. We propose a new paradigm that avoids the FBR by providing a tissue-engineered injectable implant that is completely biological and human. This non-living product will support the creation of an actual living tissue that will be long-lasting without chronic inflammation. Our strategy is based on a unique material described in the project.
The potential of this implants will be demonstrated through two work packages described in the project.
Overall, this PoC will increase the technology readiness level of our product from 1-2 to 3-4 work packages. These outcomes will justify optimizing production methods, expanding in vivo analysis, and will support a commercial endeavor targeting multiple clinical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-POC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.