Objective
Infection by rabies virus causes about 40,000-70,000 deaths per year worldwide. More than 99% of all human deaths occur in Africa, Asia and South America, most commonly involving children aged under 15 years. The recommended therapeuthic procedure for peop le suspected to be infected with this virus includes the immediate administration of both vaccine and rabies specific immunoglobulins (RIG). Prophylaxis in the form of immunoglobulins includes equine anti-rabies immunoglobulins (ERIG) or human anti-rabies Ig (HRIG), however these reagents are expensive, and in short supply especially in developing countries. One solution that is being explored is to generate a cocktail of rabies neutralising monoclonal antibodies to replace ERIG. If it were possible to gene rate enough recombinant antibodies cheaply, then this would be of enormous benefit in rabies affected countries, particularly in SE Asia and Africa In this proposal we aim to select new and cross- neutralising antibodies against lyssavirus strains using re combinant antibody phage-display technology. Two single chain Fv antibody phage display libraries will be used, a human naïve library and a synthetic murine scFv library derived from a stable protein scaffold. The selected scFvs will be tested for in vitro virus neutralization assays and up to two antibodies will be chosen for engineering back into the heavy and light chains of a human Ig, generating chimeric anti rabies Mabs. The engineered antibodies will initially be introduced into tobacco plants to as sess plant expression in plants. Ultimately, the aim is to use transgenic maize expression, but this is beyond the scope of the current application.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.