Objective
The excision of introns from eukaryotic pre-mRNA and splicing together of exons is performed by a macromolecular machine called the spliceosome. Splicing is a highly dynamic process that involves many spliceosomal intermediates. Each intermediate contains specific RNA-protein complexes called small nuclear ribonucleoprotein particles (snRNPs) and a number of additional non-snRNP proteins. It has been established that the spliceosome intermediates that are involved in the actual splicing reactions contain U2 , U5 and U6 snRNPs and that their snRNA plays a very important role in catalysing the reactions. To date, the crystal structures of a number of components of snRNPs have been reported. Detailed insight into the mechanism of splicing at the molecular level is, however, hampered by lack of structural information of the larger complexes present at the catalytic site of the spliceosome. Therefore I propose to work on those protein-RNA complexes and subsets of intermediates of the spliceosome that are involved i n the catalytic steps during splicing in crystallographic and biochemical studies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.