Objective
Intercellular communication and adhesion are involved in many developmental processes of multicellular organisms. An increase in anatomical and physiological complexity of organisms is accompanied by an expansion of gene families encoding proteins that are involved in cell-cell recognition and signalling. Prominent examples are the members of the IgSF family, which encountered a fivefold numerical increase in vertebrates compared to invertebrates, despite the total number of genes only doubling. The identif ication of novel receptor:ligand pairs of this gene family and their in vivo functional analysis would further our knowledge of vertebrate specific developmental processes. To achieve this goal, we propose to take a genome wide approach by using the zebraf ish as a model organism. This approach will be carried out in the host laboratory of Gavin Wright at the Sanger Institute and comprises the identification of genes encoding cell surface proteins of the IgSF family (by using information from the Sanger Inst itute zebrafish genome project), the detection of novel receptor:ligand pairs among them, and the assessment of their in vivo function by means of a reverse genetic approach in zebrafish. The host institution provides an ideal scientific environment to ach ieve the mentioned objectives. The applicant will provide his expertise concerning the use of the zebrafish as a genetic model organism, whilst the host institute will provide the necessary infrastructure, equipment and expertise within in the fields of bi ochemistry and proteomics. The proposed project will therefore contribute to the exchange of knowledge between two European countries coupled to the fact that the whole genome approach to be taken is particularly suitable to establish further long-term col laborations. Ultimately, this project will help us to achieve a better mechanistic understanding at a molecular level of the processes that underlie the establishment of complex vertebrate specific features.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences developmental biology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences zoology invertebrate zoology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.