Objective
The effects of ionising radiation on biological material have been studied on the tissue scale for many years. However, research to understand the processes at a molecular level has begun only recently. Relatively few experiments have been carried out on t he effects of ionising rays on key biological molecules (biomolecules) such as DNA and its constituent bases. Cross-sectional results for these interactions are highly relevant to the use of radiation in medicine.Today it is possible to isolate biomolecul es including uracil, thymine, and adenine (bases of RNA and DNA) in the gas phase. Further techniques have recently been pioneered at the Institut Galilee, Paris to produce and characterise clusters of these molecules. The IPM group are currently developin g an experiment comprising an original double mass spectrometer and a cluster source which incorporates these new techniques. This project will initially focus upon the completion of the experimental system.The apparatus will be used to study the consequen ces of high energy proton impact on a biomolecule surrounded by a fixed number of water molecules. The experiment thus represents a novel perspective spanning two traditionally independent research areas: radiobiology and the study of gas phase molecules. Biomolecule - water reactions initiated by the impact of high-velocity ions will be observed for the first time, providing important new quantitative data. Experiments will be carried out for proton impact velocities of the order of the Bragg peak (c/137). A number of cancer therapy techniques are based upon the observation that such incident radiation can dramatically degrade the reparability of DNA.The project will be carried out within the EU COST P9 network Radiation Damage in Biomolecular Systems appro ved for funding from 2003 to 2007. The interest, facilities and expertise within Europe today provide the ideal opportunity to develop new experiments in this field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.