Objective
Necrotic cell death underlies the pathology of numerous human neurodegenerative disorders. However, contrary to the remarkable progress in deciphering the biochemistry of apoptosis, little is known about the molecular mechanisms that bring about necrotic c ell death. Although mitochondria play an essential role in apoptosis, their involvement in necrosis is poorly understood. This project aims at elucidating the mitochondrial pathways involved in the regulation and proper execution of necrosis, using C. eleg ans as a model organism. Degenerative cell death of motor neurons and other nerve cells of C. elegans can easily be triggered by genetic manipulations and environmental factors. This provides the essential tools required to determine the molecular mechanis ms by which mitochondria participate in necrosis in this simple and powerful animal genetic system. To achieve this goal, we will (1) implement optical imaging methods to analyse mitochondrial structure and function in dying neurons, (2) screen the C. eleg ans genome for genes involved in mitochondrial processes essential for necrosis, analyse the function of the identified genes, and (3) delineate the mitochondrial molecular pathways responsible for necrosis in C. elegans. Dissection of the molecular mechan isms that govern mitochondrial involvement in necrosis will offer insights into disease and pathogenesis and in due course, provide novel targets for therapeutics. As such, deciphering the mitochondrial role in necrosis is of fundamental importance towards the development of educated strategies aiming to combat diseases of the nervous system, which is a priority of the Sixth Framework Programme. The proposed investigation uniquely merges the applicant¿s experience on mitochondrial research with the expertis e of the Host Institution in necrotic cell death in C. elegans. Such blending will greatly facilitate the development and transfer of research competencies, contributing to enhance EU scientific excellence.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HERAKLION-CRETE
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.