Objective
The establishment and maintenance of cell polarity is a fundamental feature of most eukaryotic cells and is crucial for the generation of cell diversity through asymmetric cell divisions in development and for the proper execution of vectorial cellular fun ctions. Par-1 kinases play instrumental roles in cell polarization from yeast to humans. However, little is known about the molecular mechanisms by which they exert their effects. The Drosophila oocyte, which is ideally suited for genetic and biochemical m anipulation, will be used as a model system to identify and characterize Par-1 targets and regulators. Specifically, a proteomic-level screen will be applied to identify Par-1 targets. In parallel, candidate molecules likely to regulate or effect Par-1 fun ctions will be examined. Finally, new tools, including Par-1 activity sensors, will be developed to monitor Par-1 regulation in vivo. Given the molecular and functional conservation of Par-1 in eukaryotes, it is likely that interacting partners isolated in Drosophila will have similar functions in other organisms, providing insight into the molecular networks through which a fundamental process such as cell polarization is achieved. The host laboratory has extensive expertise both in doing state-of-the-art Drosophila genetics, as well as in developing and exploiting new approaches, demonstrated by multiple publications in top-tier journals. Furthermore, the interdisciplinary and highly interactive environment at EMBL, as well as its state-of the-art Core Fac ilities, provide a unique opportunity for receiving high-level training and doing cutting edge research in Molecular Biology. EMBL also offers great possibilities for collaborations and networking with scientists world-wide, contributing to the enhancement of European research. As my goal is to remain in Europe from now on, my transit through EMBL will be greatly beneficial for doing top-level science and starting an independent research career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology cell polarity
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.