Objective
A fascinating feature of free-living nematodes is their ability to arrest or resume their development according to environmental cues. Parasitic nematodes are likely to similarly respond to their environment-the host-as they have a common ancestry with free-living nematodes. A potent variation of their environment is certainly the immune reaction they elicit in their host. Data is accumulating that parasites can not only thrive in immuno competent hosts, but also adapt their development accordingly.
A similar correlation between host cytokine responses and parasite development had been observed for filarial nematodes. To explore both the mechanisms and evolutionary implications of these host-parasite interactions, I intend to utilise molecular tools for an objective measurement of changes in parasite development in order to (i) identify host immune components perceived as developmental cues by filarial parasites and (ii) determine whether changes in development provide a fitness advantage to the parasite.
To achieve these aims, I will need to acquire new interdisciplinary skills in molecular biology, bioinformatics and theoretical evolutionary biology only all at hand in the host organisation to add to my knowledge of immunology and filaria morphology. I see t his as the basis for a scientific career that has both direct biomedical relevance and exciting intellectual challenges around yet unexplored aspects of filariasis that I hope to expand to other parasitic diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences evolutionary biology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.