Objective
Oxidase enzymes reliably perform oxidation reactions in very high yields and are regularly employed in organic chemistry as selective catalysts (eg. horseradish peroxidase). The utilization of enzymes, however, requires that the reaction be performed under nearly physiological conditions (aqueous solution, 37oC, pH 7). Providing a chemically more versatile and robust alternative to oxidase enzymes would be a valuable resource for synthetic chemists and is the aim of this research. In recent years, molecularly imprinted polymers (MIPs) containing transition metal catalysts have emerged as a promising new alternative to metalloenzymes.
This project aims to develop a methodology for the synthesis of iron and copper containing MIP catalysts, which imitate non-heme metallaoxidases. In order to generate polymers with oxidase-analogue metal binding sites (eg. a His-His-Carboxylate facial triad), we will employ "dummy metal complexes" having multidentate N/O-chelate ligands with polymerisable vinyl side-chains. After polymerisation under the conditions of molecular imprinting, the dummy metal ions will be cleaved off, thereby generating a rigid polymer with site-isolated binding sites, which will subsequently be occupied by the biologically relevant metal ion (e g. Fe2+). This approach circumvents some of the main problems that are frequently encountered when metallaoxidases are modelled in homogeneous solution (low solubility in water, aggregation etc.). The resulting MIPs will be stable, robust, and recyclable solids, which act as functional analogues of the respective oxidases.
A further advantage of our methodology is the possibility to modulate the microenvironment of the catalytically active metal centre using appropriate dummy complexes. This allows fine-tuning of the substrate- and regio-selectivity of the artificial oxidase. Catalytically active polymers of this kind may find applications as versatile tools in organic synthesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences polymer sciences
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.