Objective
Prostate cancer is now the leading cause of cancer related deaths in most European countries. However, knowledge of the underlying mechanisms is still scarce. The overall aim of this project is to identify new oncogenes involved in prostate cancer and assess their potential as clinical markers. The focus will be the E2F3 transcription factor that has an established role in cell cycle progression and has recently been proposed as a candidate oncogene for bladder cancer. Initial studies indicate that 70% of prostate cancers over-express E2F3.
We will combine tissue microarray (TMA) staining data from 1200 prostate cancer patients with clinical data, and statistically analyse the correlation. We will also test the hypothesis that down regulation of pBR is needed for upregulation of E2F3 to have an impact, by studies of the pBR levels in parallel with the E2F3 analysis on the TMAs. We will determine whether the upregulation is associated with increased copy number of the gene by flourescence in situ hybridisation ( FISH) onto TMAs and, finally, the biological role of E2F3 in the development of prostate cancer will be investigated by siRNA technology in prostate cancer cell lines that over-express E2F3.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.