Objectif
Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Worldwide prevalence figures estimate that there will be 246 million diabetic patients in 2007 and 380 million in 2025. Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as well as microvascular disorders leading to damage of the small blood vessels of the kidney (nephropathy), eye(retinopathy) and peripheral nerves (neuropathy). These complications impose an immense burden on the quality of life of the patients and account for more than 10% of health care costs in Europe. Therefore, novel means to prevent these devastating diabetic complications are needed. An important mean in this undertaking would be to develop tools which would make development of novel drugs for prevention of complications more feasible. The SUMMIT consortium brings together European key leaders in the field of diabetes research; scientists with a deep insight into genetics, biomarker discovery, development of novel imaging assays for assessing progression of complications, novel animal models for chronic diabetic complications, in silico models to predict development of complications and response to novel treatments. Given the track record of this unique group of scientists, it can be anticipated that they will not only during the 6-year period discover novel surrogate markers for vascular complications in diabetes, but also validate them in large representative cohorts aiming at prevention of the devastating complications.
Champ scientifique
Appel à propositions
IMI-JU-01-2008
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Régime de financement
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)Coordinateur
55218 Ingelheim
Allemagne
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Participants (25)
22100 Lund
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02130 Espoo
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17177 Stockholm
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85764 Neuherberg
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20156 Milano
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CB2 1TN Cambridge
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DD1 4HN Dundee
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EX4 4QJ Exeter
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405 30 Goeteborg
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00250 Helsinki
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00271 Helsinki
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70211 KUOPIO
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OX1 2JD Oxford
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35122 Padova
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27100 Pavia
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56126 Pisa
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20123 Milano
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20014 Turku
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EH8 9YL Edinburgh
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RG21 4FA Basingstoke
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151 85 Sodertaelje
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4070 Basel
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50121 Florence
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65929 Frankfurt Am Main
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CT13 9NJ Sandwich
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