Objective
A tight co-ordination between cell proliferation and differentiation is essential to the correct development of all multi-cellular organisms. The intercellular signalling pathway triggered by the receptor Notch is central in maintaining the co-ordination between cell cycle control and neuronal cell fate acquisition during vertebrate development. However, the mechanistic details of its action are still ill understood. This is largely due to the great anatomical and genetic complexity of the available vertebrate model systems. The ascidian, Ciona intestinalis is a basal chordate.
It is phylogenetically close to vertebrates, but morphologically and genetically very simple and well characterized. We propose to exploit the simple peripheral nervous system of Ciona intestinalis to study the interactions between Notch signalling and the cell cycle control mechanisms in chordates. Our project aims first at understanding the respective contributions of the Notch pathway and the cell cycle control machinery in defining the number of peripheral nervous system neurons in Ciona larvae.
In a second time, we will explore the connections between the two mechanisms. To this end, we will take advantage of the amenability of Ciona embryos to a large spectrum of developmental and molecular biology manipulations. The project will result in a better comprehension of the mechanisms, which regulate cell proliferation and differentiation in chordates. This may in turn lead to the identification of new genes involved in human proliferative disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MARSEILLE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.