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Development of RApid Point-of-Care test Platforms for Infectious Diseases

Objective

RAPP-ID (“Development of RApid Point-of-Care test Platforms for Infectious Diseases”) will develop a Point-of-Care Test (POCT) for rapid (hospital <2h, primary care <30min) detection of bacteria, mycobacteria, fungi, as well as viruses and host biomarkers by combining novel specific probes, novel methods of sample preparation, and demonstrated ultra-high sensitive detection methods. The platforms will also determine resistance to antimicrobial drugs. The research will focus on the biomarkers and pathogens involved in 1) Sepsis, 2) Lower Respiratory Tract Infections (LRTI), including Community-Acquired Pneumonia (CAP) and Ventilator-Associated Pneumonia (VAP), and 3) Tuberculosis (TB). Detection of bacteria, fungi and antibiotic resistance will mainly involve Nucleic Acid (NA) tests, whereas viral and host biomarker detection will mainly involve selective immunobinding with a probe or with a sensor surface. The diagnostic tests consist of in four functional modules: 1) sample collection and interfacing, 2) upconcentration and extraction, 3) signal and/or sample amplification, and 4) detection. RAPP-ID will integrate the minimum number of modules required for each disease/syndrome in a microfluidic cartridge, for which a breadboard reader with Graphical User Interface (GUI) provides the necessary optical/fluidic/electric/thermal interfaces. The integrated POCT will be validated on (spiked) reference samples and well characterised clinical samples and compared with the best reference standards and other standard available diagnostic tests.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid
  • /medical and health sciences/health sciences/infectious disease
  • /natural sciences/biological sciences/microbiology/mycology
  • /natural sciences/biological sciences/microbiology/mycology/ethnomycology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

IMI-JU-02-2009
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

JANSSEN PHARMACEUTICA NV
Address
Turnhoutseweg 30
2340 Beerse
Belgium
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Jorge Villacian (Dr)
Administrative Contact
Carol Leland (NA)

Participants (19)

UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 1 272 684
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Mrs)
UPPSALA UNIVERSITET

Participation ended

Sweden
EU contribution
€ 37 123
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pirkko Boox (Ms)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 489 154
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms)
MICROFLUIDIC CHIPSHOP GMBH
Germany
EU contribution
€ 467 400
Address
Stockholmer Strasse 20
07747 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Claudia Gärtner (Dr.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 458 075
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margo Baele (dr)
INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Belgium
EU contribution
€ 229 726
Address
Kapeldreef 75
3001 Leuven
Activity type
Research Organisations
Administrative Contact
Christine Van Houtven (Mrs.)
Q-LINEA AB
Sweden
EU contribution
€ 491 845
Address
Dag Hammarskjolds Vag 58A
75237 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jonas Jarvius (PhD)
LIONEX GMBH
Germany
EU contribution
€ 476 900
Address
Salzdahlumer Strasse 196
38126 Braunschweig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stephanie Guetif (Dipl. FH BW)
MOBIDIAG OY

Participation ended

Finland
EU contribution
€ 174 455
Address
Tukholmankatu 8
00290 Helsinki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Antti Ojala (Mr.)
UNIVERSITEIT TWENTE
Netherlands
EU contribution
€ 364 003
Address
Drienerlolaan 5
7522 NB Enschede
Activity type
Higher or Secondary Education Establishments
Administrative Contact
B.J. Pals (Mr.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 75 379
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eevi Laukkanen (Ms)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 60 500
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fabricio JANTARADA (B.S.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 366 540
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sarah Malevé (Ms.)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 1 327 277
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erika Appel (Administrative Responsible)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elaine Alison Irving (Dr)
GLAXOSMITHKLINE VACCINES SRL
Italy
Address
Via Fiorentina 1
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Luca Bassini (Dr)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Annabelle Milla (Dr. (Pharm D))
MERCK SHARP & DOHME CORP
United States
Address
One Merck Drive
08889 Whitehouse Station Nj
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christine McCallum (Project Manager)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 537 377
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ann Nielsen (Ms)