Development of RApid Point-of-Care test Platforms for Infectious Diseases

Project Information

RAPP-ID

Grant agreement ID: 115153

Project closed

Start date 1 April 2011

End date 30 September 2016

Funded under

• Specific Programme "Cooperation": Joint Technology Initiatives

Total cost € 15 927 300,00

EU contribution € 6 828 438,00

Coordinated by

JANSSEN PHARMACEUTICA NV
Belgium

Objective

RAPP-ID (“Development of RApid Point-of-Care test Platforms for Infectious Diseases”) will develop a Point-of-Care Test (POCT) for rapid (hospital <2h, primary care <30min) detection of bacteria, mycobacteria, fungi, as well as viruses and host biomarkers by combining novel specific probes, novel methods of sample preparation, and demonstrated ultra-high sensitive detection methods. The platforms will also determine resistance to antimicrobial drugs. The research will focus on the biomarkers and pathogens involved in 1) Sepsis, 2) Lower Respiratory Tract Infections (LRTI), including Community-Acquired Pneumonia (CAP) and Ventilator-Associated Pneumonia (VAP), and 3) Tuberculosis (TB). Detection of bacteria, fungi and antibiotic resistance will mainly involve Nucleic Acid (NA) tests, whereas viral and host biomarker detection will mainly involve selective immunobinding with a probe or with a sensor surface. The diagnostic tests consist of in four functional modules: 1) sample collection and interfacing, 2) upconcentration and extraction, 3) signal and/or sample amplification, and 4) detection. RAPP-ID will integrate the minimum number of modules required for each disease/syndrome in a microfluidic cartridge, for which a breadboard reader with Graphical User Interface (GUI) provides the necessary optical/fluidic/electric/thermal interfaces. The integrated POCT will be validated on (spiked) reference samples and well characterised clinical samples and compared with the best reference standards and other standard available diagnostic tests.

Fields of science

• natural sciences › biological sciences › microbiology › bacteriology
• medical and health sciences › health sciences › infectious diseases
• natural sciences › biological sciences › microbiology › mycology
• medical and health sciences › clinical medicine › pneumology › tuberculosis
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › antibiotic resistance

Programme(s)

• FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives

Topic(s)

• IMI-JU-02-2009-04 - Infectious Diseases – Diagnostic Tools

Call for proposal

IMI-JU-02-2009
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

JANSSEN PHARMACEUTICA NV

• EU contribution: No data
• Address: TURNHOUTSEWEG 30 ; 2340 Beerse ; Belgium
• Region: Vlaams Gewest › Prov. Antwerpen › Arr. Turnhout
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Principal investigator: Jorge Villacian (Dr)
• Administrative Contact: Carol Leland (NA)
• Total cost: No data

Participants (19)

UNIVERSITEIT ANTWERPEN

Belgium

• EU contribution: € 1 272 684,00
• Address: PRINSSTRAAT 13 ; 2000 Antwerpen
• Region: Vlaams Gewest › Prov. Antwerpen › Arr. Antwerpen
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Anne Adams (Mrs)
• Total cost: No data

UPPSALA UNIVERSITET

Participation ended

Sweden

• EU contribution: € 37 123,00
• Address: VON KRAEMERS ALLE 4 ; 751 05 Uppsala
• Region: Östra Sverige › Östra Mellansverige › Uppsala län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Pirkko Boox (Ms)
• Total cost: No data

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

• EU contribution: € 489 154,00
• Address: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Renata Schaeffer (Ms)
• Total cost: No data

MICROFLUIDIC CHIPSHOP GMBH

Germany

• EU contribution: € 467 400,00
• Address: STOCKHOLMER STRASSE 20 ; 07747 Jena
• Region: Thüringen › Thüringen › Jena, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Claudia Gärtner (Dr.)
• Total cost: No data

UNIVERSITEIT GENT

Belgium

• EU contribution: € 458 075,00
• Address: SINT PIETERSNIEUWSTRAAT 25 ; 9000 Gent
• Region: Vlaams Gewest › Prov. Oost-Vlaanderen › Arr. Gent
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Margo Baele (dr)
• Total cost: No data

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM

Belgium

• EU contribution: € 229 726,00
• Address: KAPELDREEF 75 ; 3001 Leuven
• Region: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Activity type: Research Organisations
• Administrative Contact: Christine Van Houtven (Mrs.)
• Total cost: No data

Q-linea

Sweden

• EU contribution: € 491 845,00
• Address: Dag Hammarskjölds väg ; 5-75237 Uppsala
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Jonas Jarvius (PhD)
• Total cost: No data

LIONEX GMBH

Germany

• EU contribution: € 476 900,00
• Address: Salzdahlumer Strasse 196 ; 38126 Braunschweig
• Region: Niedersachsen › Braunschweig › Braunschweig, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Stephanie Guetif (Dipl. FH BW)
• Total cost: No data

Mobidiag Oy

Participation ended

Finland

• EU contribution: € 174 455,00
• Address: Tukholmankatu ; 00290 Helsinki
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Antti Ojala (Mr.)
• Total cost: No data

UNIVERSITEIT TWENTE

Netherlands

• EU contribution: € 364 003,00
• Address: DRIENERLOLAAN 5 ; 7522 NB Enschede
• Region: Oost-Nederland › Overijssel › Twente
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: B.J. Pals (Mr.)
• Total cost: No data

CARDIFF UNIVERSITY

United Kingdom

• EU contribution: € 75 379,00
• Address: NEWPORT ROAD 30 36 ; CF24 0DE Cardiff
• Region: Wales › East Wales › Cardiff and Vale of Glamorgan
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eevi Laukkanen (Ms)
• Total cost: No data

UNIVERSITE DE GENEVE

Switzerland

• EU contribution: € 60 500,00
• Address: RUE DU GENERAL DUFOUR 24 ; 1211 Geneve
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Genève
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Fabricio JANTARADA (B.S.)
• Total cost: No data

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

• EU contribution: € 366 540,00
• Address: OUDE MARKT 13 ; 3000 Leuven
• Region: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Sarah Malevé (Ms.)
• Total cost: No data

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

• EU contribution: € 1 327 277,00
• Address: BRINELLVAGEN 8 ; 100 44 Stockholm
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Erika Appel (Administrative Responsible)
• Total cost: No data

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.

United Kingdom

• EU contribution: No data
• Address: Great West Road 980 ; TW89GS Brentford
• Region: London › Outer London — West and North West › Hounslow and Richmond upon Thames
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Elaine Alison Irving (Dr)
• Total cost: No data

GLAXOSMITHKLINE VACCINES SRL

Italy

• EU contribution: No data
• Address: VIA FIORENTINA 1 ; 53100 SIENA
• Region: Centro (IT) › Toscana › Siena
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Luca Bassini (Dr)
• Total cost: No data

SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT

France

• EU contribution: No data
• Address: 82 AVENUE RASPAIL ; 94250 GENTILLY
• Region: Ile-de-France › Ile-de-France › Val-de-Marne
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Annabelle Milla (Dr. (Pharm D))
• Total cost: No data

MERCK SHARP & DOHME CORP

United States

• EU contribution: No data
• Address: ONE MERCK DRIVE ; 08889 Whitehouse Station Nj
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Christine McCallum (Project Manager)
• Total cost: No data

STOCKHOLMS UNIVERSITET

Sweden

• EU contribution: € 537 377,00
• Address: UNIVERSITETSVAGEN 10 ; 10691 Stockholm
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ann Nielsen (Ms)
• Total cost: No data