The Open Pharmacological Concepts Triple Store

Project Information

OPEN PHACTS

Grant agreement ID: 115191

Project closed

Start date 1 March 2011

End date 29 February 2016

Funded under

• Specific Programme "Cooperation": Joint Technology Initiatives

Total cost € 20 782 066,00

EU contribution € 11 466 433,00

Coordinated by

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom

Objective

Drug discovery is data-hungry and all major pharmaceutical companies maintain extensive in-house instances of public data alongside internal. Analysis and hypothesis generation for drug-discovery projects requires assembly, overlay and comparison of data from many sources, requiring shared identifiers and common semantics. Expression profiles need to be overlaid with gene or pathway identifiers and reports on compound pharmacology. Alignment and integration of internal and public data and information sources is a significant effort and the process is repeated across companies, institutes and academic laboratories. This represents a significant waste and an opportunity cost.

To address these challenges, the Open PHACTS project will develop an open access innovation platform, Open Pharmacological Space (OPS), via a semantic web approach. OPS will comprise data, vocabularies and infrastructure needed to accelerate drug-oriented research. This semantic integration hub will remove key bottlenecks in small molecule drug discovery: disparate information sources, lack of standards and common identifiers, guided by well defined research questions from drug discovery.

Workflows for data capture, processing, interoperability, visualization, and chemogenomics will be developed creating a comprehensive Systems Chemical Biology Analysis Network. Security issues around proprietary data, shared via the Open PHACTS Discovery Platform and accessible for safe querying and reasoning will be properly addressed with expert trusted parties.

The Open PHACTS consortium comprises 20 European academic and SME partners, with leading experts in the fields of data mining, annotation, small molecule data storage and manipulation, target bioinformatics, RDF information handling, massive in silico reasoning and chemical biology. The 10 EFPIA members of Open PHACTS will contribute drug discovery expertise, data sets, software engineering and programming capacity to the project.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › computer and information sciences › software
• natural sciences › computer and information sciences › data science › data mining
• natural sciences › computer and information sciences › internet › semantic web

Programme(s)

• FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives

Topic(s)

• IMI-JU-02-2009-08 - Knowledge Management – Open Pharmacological Space

Call for proposal

IMI-JU-02-2009
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.

• EU contribution: No data
• Address: Great West Road 980 ; TW89GS Brentford ; United Kingdom
• Region: London › Outer London — West and North West › Hounslow and Richmond upon Thames
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Principal investigator: Stefan Senger (Dr)
• Administrative Contact: Karen Louise Philpott (Dr)
• Total cost: No data

Participants (30)

UNIVERSITAT WIEN

Austria

• EU contribution: € 1 640 800,00
• Address: UNIVERSITATSRING 1 ; 1010 Wien
• Region: Ostösterreich › Wien › Wien
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Anika Robl (MA)
• Total cost: No data

DANMARKS TEKNISKE UNIVERSITET

Denmark

• EU contribution: € 649 038,00
• Address: ANKER ENGELUNDS VEJ 101 ; 2800 Kongens Lyngby
• Region: Danmark › Hovedstaden › Københavns omegn
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Arturas Maslauskas (Mr.)
• Total cost: No data

UNIVERSITY OF HAMBURG

Germany

• EU contribution: € 483 011,00
• Address: MITTELWEG 177 ; 20148 Hamburg
• Region: Hamburg › Hamburg › Hamburg
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Martin Pagel de Souza (Mr.)
• Total cost: No data

BIOSOLVEIT GMBH

Germany

• EU contribution: € 576 364,00
• Address: AN DER ZIEGELEI 79 ; 53757 Sankt Augustin
• Region: Nordrhein-Westfalen › Köln › Rhein-Sieg-Kreis
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Gloria Kraschinski (Ms.)
• Total cost: No data

CONSORCIO MAR PARC DE SALUT DE BARCELONA

Spain

• EU contribution: € 724 540,00
• Address: PASEO MARITIM 25-29 ; 08003 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Andreu Fort (Mr)
• Total cost: No data

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

• EU contribution: € 611 304,00
• Address: ALBINUSDREEF 2 ; 2333 ZA Leiden
• Region: West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Rudi Esveld (bc.)
• Total cost: No data

THE ROYAL SOCIETY OF CHEMISTRY

United Kingdom

• EU contribution: € 985 540,00
• Address: Milton Road - Thomas Graham House - Science Park ; CB4 0WF CAMBRIDGE
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Other
• Administrative Contact: Richard KIDD (Mr)
• Total cost: No data

STICHTING VU

Netherlands

• EU contribution: € 760 630,00
• Address: DE BOELELAAN 1105 ; 1081 HV Amsterdam
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Dirkje Schinkelshoek (Mrs.)
• Total cost: No data

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III

Spain

• EU contribution: € 390 200,00
• Address: C MELCHOR FERNANDEZ ALMAGRO 3 ; 28029 Madrid
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Research Organisations
• Administrative Contact: Juan Arroyo (Mr)
• Total cost: No data

THE UNIVERSITY OF MANCHESTER

United Kingdom

• EU contribution: € 911 144,00
• Address: OXFORD ROAD ; M13 9PL Manchester
• Region: North West (England) › Greater Manchester › Manchester
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Phillip McDonald (Mr)
• Total cost: No data

UNIVERSITEIT MAASTRICHT

Netherlands

• EU contribution: € 560 308,00
• Address: MINDERBROEDERSBERG 4 ; 6200 MD Maastricht
• Region: Zuid-Nederland › Limburg (NL) › Zuid-Limburg
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Pascal Stevens (MSc RC)
• Total cost: No data

Academic Concept Knowledge Limited

Participation ended

United Kingdom

• EU contribution: € 359 019,00
• Address: Norman Avenue ; KT17 3AB Epsom
• Administrative Contact: John A Michael (Commercial Director)
• Total cost: No data

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Spain

• EU contribution: € 357 520,00
• Address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N ; 15782 Santiago De Compostela
• Region: Noroeste › Galicia › A Coruña
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Fernando Sedano Arnaez (Dr.)
• Total cost: No data

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN

Germany

• EU contribution: € 414 263,00
• Address: REGINA PACIS WEG 3 ; 53113 Bonn
• Region: Nordrhein-Westfalen › Köln › Bonn, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Gertrud Frankenreiter (Ms.)
• Total cost: No data

ASTRAZENECA AB

Sweden

• EU contribution: No data
• Address: Vastra Maelarhamnen ; 151 85 Sodertaelje
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Eva Lindgren (Mrs.)
• Total cost: No data

PFIZER LIMITED

United Kingdom

• EU contribution: No data
• Address: RAMSGATE ROAD ; CT13 9NJ Sandwich
• Region: South East (England) › Kent › East Kent
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Olga Krylova (Dr)
• Total cost: No data

ESTEVE PHARMACEUTICALS, SA

Spain

• EU contribution: No data
• Address: PASSEIG DE LA ZONA FRANCA 109, 4A PLANTA ; 08038 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Eduard Valenti (Dr)
• Total cost: No data

NOVARTIS PHARMA AG

Switzerland

• EU contribution: No data
• Address: LICHTSTRASSE 35 ; 4056 Basel
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Barbara Stolz (PhD)
• Total cost: No data

MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN

Germany

• EU contribution: No data
• Address: FRANKFURTER STRASSE 250 ; 64293 Darmstadt
• Region: Hessen › Darmstadt › Darmstadt, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Ninog Péresse (Mrs.)
• Total cost: No data

H. LUNDBECK AS

Denmark

• EU contribution: No data
• Address: OTTILIAVEJ 7-9 ; 2500 Valby
• Region: Danmark › Hovedstaden › Byen København
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Ejner Knud Moltzen (Mr.)
• Total cost: No data

ELI LILLY AND COMPANY LTD

United Kingdom

• EU contribution: No data
• Address: LILLY HOUSE BASINGVIEW ; RG21 4FA Basingstoke
• Region: South East (England) › Hampshire and Isle of Wight › North Hampshire
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Birgit Steckel-Hamann (Dr)
• Total cost: No data

STICHTING DTL PROJECTS

Netherlands

• EU contribution: € 280 350,00
• Address: JAARBEURSPLEIN 6, 6TH FLOOR BEATRIXGEBOUW JAARBEURS ; 3521 AL Utrecht
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Research Organisations
• Administrative Contact: Leonie Hek (Miss)
• Total cost: No data

SIB SWISS INSTITUTE OF BIOINFORMATICS

Switzerland

• EU contribution: € 568 776,00
• Address: RUE MICHEL SERVET 1 CMU ; 1206 Geneve
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Genève
• Activity type: Research Organisations
• Administrative Contact: Jocelyne BOCQUET (Head of finances)
• Total cost: No data

Connected Discovery Ltd

United Kingdom

• EU contribution: € 386 238,00
• Address: The Strand ; CT147DP Walmer, Deal
• Administrative Contact: Bryn Williams-Jones (Mr)
• Total cost: No data

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

• EU contribution: € 183 340,00
• Address: Meyerhofstrasse 1 ; 69117 Heidelberg
• Region: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Activity type: Research Organisations
• Administrative Contact: Agnieszka Egan (Mrs)
• Total cost: No data

JANSSEN PHARMACEUTICA NV

Belgium

• EU contribution: No data
• Address: TURNHOUTSEWEG 30 ; 2340 Beerse
• Region: Vlaams Gewest › Prov. Antwerpen › Arr. Turnhout
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Koen Meeussen (Dr.)
• Total cost: No data

OPENLINK GROUP LIMITED

United Kingdom

• EU contribution: € 413 890,00
• Address: PURLEY WAY AIRPORT HOUSE 137 ; CR0 0XZ CROYDON
• Region: London › Outer London — South › Croydon
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Hugh Williams (Mr)
• Total cost: No data

OPEN PHACTS FOUNDATION LBG

United Kingdom

• EU contribution: € 121 195,00
• Address: MILTON ROAD 290 292 SCIENCE PARK THOMAS GRAHAM HOUSE ; CB4 0WF Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Research Organisations
• Administrative Contact: Richard Kidd (Mr)
• Total cost: No data

ALMIRALL SA

Spain

• EU contribution: No data
• Address: GENERAL MITRE 151 ; 08022 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: JORGE BELETA SUPERVIA (Dr.)
• Total cost: No data

SciBite Limited

United Kingdom

• EU contribution: € 88 963,00
• Address: Office 8 ; TN40 1QF Bexhill-On-Sea
• Administrative Contact: Lee Harland (Director)
• Total cost: No data