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The Open Pharmacological Concepts Triple Store

Objective

Drug discovery is data-hungry and all major pharmaceutical companies maintain extensive in-house instances of public data alongside internal. Analysis and hypothesis generation for drug-discovery projects requires assembly, overlay and comparison of data from many sources, requiring shared identifiers and common semantics. Expression profiles need to be overlaid with gene or pathway identifiers and reports on compound pharmacology. Alignment and integration of internal and public data and information sources is a significant effort and the process is repeated across companies, institutes and academic laboratories. This represents a significant waste and an opportunity cost.

To address these challenges, the Open PHACTS project will develop an open access innovation platform, Open Pharmacological Space (OPS), via a semantic web approach. OPS will comprise data, vocabularies and infrastructure needed to accelerate drug-oriented research. This semantic integration hub will remove key bottlenecks in small molecule drug discovery: disparate information sources, lack of standards and common identifiers, guided by well defined research questions from drug discovery.

Workflows for data capture, processing, interoperability, visualization, and chemogenomics will be developed creating a comprehensive Systems Chemical Biology Analysis Network. Security issues around proprietary data, shared via the Open PHACTS Discovery Platform and accessible for safe querying and reasoning will be properly addressed with expert trusted parties.

The Open PHACTS consortium comprises 20 European academic and SME partners, with leading experts in the fields of data mining, annotation, small molecule data storage and manipulation, target bioinformatics, RDF information handling, massive in silico reasoning and chemical biology. The 10 EFPIA members of Open PHACTS will contribute drug discovery expertise, data sets, software engineering and programming capacity to the project.

Field of science

  • /natural sciences/computer and information sciences/software
  • /natural sciences/computer and information sciences/internet/semantic web
  • /medical and health sciences/basic medicine/pharmacology and pharmacy
  • /natural sciences/computer and information sciences/data science/data mining

Call for proposal

IMI-JU-02-2009
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
Address
Great West Road 980
TW89GS Brentford
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Stefan Senger (Dr)
Administrative Contact
Karen Louise Philpott (Dr)

Participants (30)

UNIVERSITAT WIEN
Austria
EU contribution
€ 1 640 800
Address
Universitatsring 1
1010 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anika Robl (MA)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 649 038
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arturas Maslauskas (Mr.)
UNIVERSITAET HAMBURG
Germany
EU contribution
€ 483 011
Address
Mittelweg 177
20148 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Pagel de Souza (Mr.)
BioSolveIT GmbH
Germany
EU contribution
€ 576 364
Address
An Der Ziegelei
53757 Sankt Augustin
Administrative Contact
Gloria Kraschinski (Ms.)
CONSORCIO MAR PARC DE SALUT DE BARCELONA
Spain
EU contribution
€ 724 540
Address
Paseo Maritim 25-29
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Andreu Fort (Mr)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 611 304
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rudi Esveld (bc.)
THE ROYAL SOCIETY OF CHEMISTRY
United Kingdom
EU contribution
€ 985 540
Address
Milton Road - Thomas Graham House - Science Park
CB4 0WF Cambridge
Activity type
Other
Administrative Contact
Richard KIDD (Mr)
STICHTING VU
Netherlands
EU contribution
€ 760 630
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dirkje Schinkelshoek (Mrs.)
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
EU contribution
€ 390 200
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Juan Arroyo (Mr)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 911 144
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Phillip McDonald (Mr)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 560 308
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pascal Stevens (MSc RC)
Academic Concept Knowledge Limited

Participation ended

United Kingdom
EU contribution
€ 359 019
Address
Norman Avenue
KT17 3AB Epsom
Administrative Contact
John A Michael (Commercial Director)
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
EU contribution
€ 357 520
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fernando Sedano Arnaez (Dr.)
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
EU contribution
€ 414 263
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gertrud Frankenreiter (Ms.)
ASTRAZENECA AB
Sweden
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Lindgren (Mrs.)
PFIZER LIMITED
United Kingdom
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olga Krylova (Dr)
ESTEVE PHARMACEUTICALS, SA
Spain
Address
Passeig De La Zona Franca 109, 4A Planta
08038 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eduard Valenti (Dr)
NOVARTIS PHARMA AG
Switzerland
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barbara Stolz (PhD)
Merck KGaA
Germany
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ninog Péresse (Mrs.)
H. LUNDBECK AS
Denmark
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ejner Knud Moltzen (Mr.)
Eli Lilly and Company Limited
United Kingdom
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Steckel-Hamann (Dr)
STICHTING DTL PROJECTS
Netherlands
EU contribution
€ 280 350
Address
Jaarbeursplein 6, 6Th Floor Beatrixgebouw Jaarbeurs
3521 AL Utrecht
Activity type
Research Organisations
Administrative Contact
Leonie Hek (Miss)
SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 568 776
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
Administrative Contact
Jocelyne BOCQUET (Head of finances)
Connected Discovery Ltd
United Kingdom
EU contribution
€ 386 238
Address
The Strand
CT147DP Walmer, Deal
Administrative Contact
Bryn Williams-Jones (Mr)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 183 340
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Agnieszka Egan (Mrs)
JANSSEN PHARMACEUTICA NV
Belgium
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Koen Meeussen (Dr.)
OPENLINK GROUP LIMITED
United Kingdom
EU contribution
€ 413 890
Address
Purley Way Airport House 137
CR0 0XZ Croydon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hugh Williams (Mr)
OPEN PHACTS FOUNDATION LBG
United Kingdom
EU contribution
€ 121 195
Address
Milton Road 290 292 Science Park Thomas Graham House
CB4 0WF Cambridge
Activity type
Research Organisations
Administrative Contact
Richard Kidd (Mr)
ALMIRALL SA
Spain
Address
General Mitre 151
08022 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
JORGE BELETA SUPERVIA (Dr.)
SciBite Limited
United Kingdom
EU contribution
€ 88 963
Address
Office 8
TN40 1QF Bexhill-on-sea
Administrative Contact
Lee Harland (Director)