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Collaboration on the Optimisation of Macromolecular Pharmaceutical Access to Cellular Targets

Objective

Most biopharmaceuticals (BP) currently on the market are recombinant proteins which are parenterally administered. These would benefit from more patient-friendly routes of administration. Moreover, new classes of BP (e.g. siRNA, miRNA, DARPins) with specificity for intracellular targets hold promise but await the advent of efficient delivery systems before their potential can be realised into therapeutic products. Solving the bottleneck of BP delivery is one of the main incentives of the pharmaceutical industry as this would allow a broadening of the spectrum of potential targets for therapeutic intervention needed to fill their drug pipelines. COMPACT represents Europe’s frontrunners in pharmaceutics, nanotechnology, biology, chemistry, engineering and imaging who will work in close collaboration with EFPIA on the delivery issues with BP. The main objectives are (1) to identify and understand transport pathways across biological barriers and cell membranes that can be utilized for delivery of BP, (2) to construct, characterise and preclincally validate BP formulations for non-invasive delivery of BP, with an emphasis on oral, airway and (trans)dermal delivery and for transport over the BBB. This will be achieved by setting up sophisticated in vitro models of biological barriers and appropriate animal models to find pathways that can be used for effective delivery of BP. In parallel, we will alter the BP either by chemical or biological engineering or by nano-formulations to enhance their uptake or transport over biological barriers.To be able to follow the transport,advanced imaging techniques will be utilised. The unique feature of this consortium is the alliance of experts in different research fields that complement each other in this challenging task. It is only the concerted action of such an interdisciplinary consortium that can make a difference in finding constructive solutions to the problem of poor bioavailability and target accessibility of BP.

Call for proposal

IMI-JU-04-2011
See other projects for this call

Coordinator

SANOFI-AVENTIS DEUTSCHLAND GMBH
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Ekkehard Leberer (Prof. Dr.)
Administrative Contact
Nathalie Piton (Dr)

Participants (21)

UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 1 712 509
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin de Geest (mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 984 291
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kenneth Lindholm (Senior adviser)
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 550 611
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
Administrative Contact
Michael Strätz (Dr.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 675 229
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eevi Laukkanen (Miss)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 618 030
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maryam Hansson Edalat (Dr.)
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 491 013
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefan Cornelis de Graaf (Dr)
UNIVERSITAT WIEN
Austria
EU contribution
€ 837 742
Address
Universitatsring 1
1010 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helmut Schaschl (Dr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 201 594
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monika Bernhardt (/)
University of Zurich
Switzerland
EU contribution
€ 612 981
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Plückthun (Prof.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 491 133
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margo Baele (Dr.)
PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT
Hungary
EU contribution
€ 559 740
Address
Derkovits Fasor 7-11
6726 Szeged
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Letoha Tamas (MD, PhD)
BIONEER A/S
Denmark
EU contribution
€ 487 563
Address
Kogle Alle 2
2970 Hoersholm
Activity type
Research Organisations
Administrative Contact
Lars H Pedersen (Director R & D)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 444 273
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sanna-Maija Kiviranta (PhD)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 786 582
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ton Brouwer (mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 731 618
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Pialek (Head of European Team)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sally Miles (-)
ABBVIE DEUTSCHLAND GMBH & CO KG
Germany
Address
Mainzer Str. 81
65205 Wiesbaden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frank-Christophe Lintz (Dr.)
NOVO NORDISK A/S
Denmark
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Toby Brunt (Mr)
Merck KGaA
Germany
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ninog Péresse (Mrs.)
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Address
Binger Strasse
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rolf Göggel (Dr.)
PFIZER LIMITED
United Kingdom
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olga Krylova (Dr)