Objective
StemBANCC, comprising internationally renowned investigators, is ideally positioned to deliver a unique European biorepository and drug discovery pipeline based upon human induced pluripotent stem cells (hiPSC). This unrivalled opportunity will address the pressing therapeutic need in neurodegeneration, neurodysfunction and diabetes. We have immediate access to richly phenotyped subjects with a wealth of clinical data. Furthermore our cohorts include genetic and genome data, allowing us to carefully select subjects for hiPSC based disease model development. This clinical-genetic stratification is essential to ensure that cellular models display disease and therapy relevant phenotypes. hiPSC reprogramming is undertaken by an internationally respected centre, providing robust, reliable and timely delivery of hiPSCs; ensures the biorepository only houses quality assured hiPSC lines; and reduces unwanted variability in assays. We have leading experts in hiPSC differentiation, providing protocols with over 99% efficiency in producing cortical excitatory neurons and cardiomyocytes, which following up-scaling will meet demands of high throughput assays. StemBANCC will deliver a comprehensive ‘omics’ dataset on over 1500 stem cell lines. This includes cells taken at different lineage stages, after therapeutic challenge, monogenic and complex variants, and with matched isogenic controls. The integration of this network/pathway data will define core etiopathological processes, therapeutic generality, reveal on- and off-target effects, allow candidate therapeutic repositioning and decouple tolerance and toxicity pathways. The large-scale integrated datasets then directly guide the disease specific targeted assays, designed to maximize utility in low and high- through compound screening programs. Assay development undertaken by the StemBANCC proposed central test facility thereby provides the final component of our hiPSC platform for drug discovery, development and safety.
Fields of science
- natural sciencesbiological sciencesneurobiology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesbasic medicinetoxicology
Call for proposal
IMI-JU-04-2011
See other projects for this call
Coordinator
F. HOFFMANN-LA ROCHE AG
EU contribution
No data
Address
GRENZACHERSTRASSE 124
4070 Basel
Switzerland
4070 Basel
Switzerland
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Region
Schweiz/Suisse/Svizzera
Nordwestschweiz
Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jason Hannon (DR.)
Principal investigator
Martin Graf (-)
Links
Total cost
No data
Participants (37)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 9 099 682,00
Address
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
OX1 2JD Oxford
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Region
South East (England)
Berkshire, Buckinghamshire and Oxfordshire
Oxfordshire
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gill Wells (Mrs)
Links
Total cost
No data
CONCENTRIS RESEARCH MANAGEMENT GMBH
Germany
EU contribution
€ 623 147,00
Address
Ludwigstr. 4
82256 FURSTENFELDBRUCK
82256 FURSTENFELDBRUCK
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Region
Bayern
Oberbayern
Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ameli Schwalber (Dr.)
Links
Total cost
No data
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 1 080 474,00
Address
STRAND
WC2R 2LS London
WC2R 2LS London
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Region
London
Inner London — West
Westminster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Walker (Mr.)
Links
Total cost
No data
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 1 462 000,00
Address
GOWER STREET
WC1E 6BT London
WC1E 6BT London
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Region
London
Inner London — West
Camden and City of London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms)
Links
Total cost
No data
NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 881 996,00
Address
MARKWIESENSTRASSE 55
72770 Reutlingen
72770 Reutlingen
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Region
Baden-Württemberg
Tübingen
Reutlingen
Activity type
Research Organisations
Administrative Contact
Hugo Haemmerle (Prof.Dr.)
Links
Total cost
No data
HUMAN CELL DESIGN
France
EU contribution
€ 783 535,00
Address
PLACE PIERRE POTIER CENTRE PIERRE POTIER CANCEROPOLE ENTREE B 1
31000 Toulouse
31000 Toulouse
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Region
Occitanie
Midi-Pyrénées
Haute-Garonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guillaume COSTECALDE (Mr.)
Links
Total cost
No data
ISLENSK ERFDAGREINING EHF
Participation ended
Iceland
EU contribution
No data
Address
STURLUGOTU 8
101 Reykjavik
101 Reykjavik
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Region
Ísland
Ísland
Höfuðborgarsvæði
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frosti Jonsson (Mr.)
Links
Total cost
No data
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 1 921 723,00
Address
OLD COLLEGE, SOUTH BRIDGE
EH8 9YL Edinburgh
EH8 9YL Edinburgh
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Region
Scotland
Eastern Scotland
Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fiona Edler (Ms)
Links
Total cost
No data
REGION HOVEDSTADEN
Denmark
EU contribution
€ 167 771,00
Address
KONGENS VAENGE 2
3400 Hillerod
3400 Hillerod
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Region
Danmark
Hovedstaden
Nordsjælland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Kirsten Hjelm (Ms)
Links
Total cost
No data
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 175 284,00
Address
Edgbaston
B15 2TT Birmingham
B15 2TT Birmingham
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Region
West Midlands (England)
West Midlands
Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms)
Links
Total cost
No data
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 758 325,00
Address
INGOLSTADTER LANDSTRASSE 1
85764 Neuherberg
85764 Neuherberg
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Region
Bayern
Oberbayern
München, Landkreis
Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
Links
Total cost
No data
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 383 476,00
Address
Chariteplatz 1
10117 Berlin
10117 Berlin
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Region
Berlin
Berlin
Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms)
Links
Total cost
No data
UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 769 457,00
Address
RATZEBURGER ALLEE 160
23562 Lubeck
23562 Lubeck
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Region
Schleswig-Holstein
Schleswig-Holstein
Lübeck, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maik Eckelt (Mr)
Links
Total cost
No data
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 1 886 399,00
Address
KINGS GATE
NE1 7RU Newcastle Upon Tyne
NE1 7RU Newcastle Upon Tyne
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Region
North East (England)
Northumberland and Tyne and Wear
Tyneside
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Darren Storey (Mr)
Links
Total cost
No data
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 383 476,00
Address
QUARTIER UNIL CENTRE - BATIMENT UNICENTRE
1015 LAUSANNE
1015 LAUSANNE
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Region
Schweiz/Suisse/Svizzera
Région lémanique
Vaud
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie-Gabrielle Zurich (Dr.)
Links
Total cost
No data
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 383 476,00
Address
CHRISTOPH PROBST PLATZ 1
6020 Innsbruck
6020 Innsbruck
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Region
Westösterreich
Tirol
Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wolfram Rieneck (Dr.)
Links
Total cost
No data
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 575 214,00
Address
RUE DU GENERAL DUFOUR 24
1211 Geneve
1211 Geneve
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Region
Schweiz/Suisse/Svizzera
Région lémanique
Genève
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emmanouil DERMITZAKIS (Professor)
Links
Total cost
No data
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 006 625,00
Address
RUE DE TOLBIAC 101
75654 Paris
75654 Paris
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Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Administrative Contact
Lyddie LAALAND (Madame)
Links
Total cost
No data
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 958 690,00
Address
TRINITY LANE THE OLD SCHOOLS
CB2 1TN Cambridge
CB2 1TN Cambridge
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Region
East of England
East Anglia
Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jo Dekkers (Dr)
Links
Total cost
No data
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 819 681,00
Address
Carl-Neuberg-Strasse 1
30625 Hannover
30625 Hannover
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Region
Niedersachsen
Hannover
Region Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
Links
Total cost
No data
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 431 411,00
Address
RAMAT AVIV
69978 Tel Aviv
69978 Tel Aviv
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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms)
Links
Total cost
No data
UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE
France
EU contribution
€ 250 877,00
Address
RUE DU DOCTEUR SCHWEITZER CS 60319 CENTRE PIERRE GUILLAUMAT
60203 Compiegne Cedex
60203 Compiegne Cedex
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Region
Hauts-de-France
Picardie
Oise
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stéphanie ROSSARD (Dr)
Links
Total cost
No data
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 460 172,00
Address
CAMPUS VALLA
581 83 Linkoping
581 83 Linkoping
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Region
Östra Sverige
Östra Mellansverige
Östergötlands län
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pia Heidenberg (Controller)
Links
Total cost
No data
ABBVIE DEUTSCHLAND GMBH & CO KG
Germany
EU contribution
No data
Address
MAINZER STR. 81
65205 Wiesbaden
65205 Wiesbaden
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Region
Hessen
Darmstadt
Wiesbaden, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frank-Christophe Lintz (Dr.)
Links
Total cost
No data
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
EU contribution
No data
Address
BINGER STRASSE
55218 Ingelheim
55218 Ingelheim
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Region
Rheinland-Pfalz
Rheinhessen-Pfalz
Mainz-Bingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marcus Kostka (Dr.)
Links
Total cost
No data
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
No data
Address
TURNHOUTSEWEG 30
2340 Beerse
2340 Beerse
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Region
Vlaams Gewest
Prov. Antwerpen
Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Henk Sipma (Dr)
Links
Total cost
No data
ELI LILLY AND COMPANY LTD
United Kingdom
EU contribution
No data
Address
LILLY HOUSE BASINGVIEW
RG21 4FA Basingstoke
RG21 4FA Basingstoke
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Region
South East (England)
Hampshire and Isle of Wight
North Hampshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Steckel-Hamann (Dr)
Links
Total cost
No data
MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
EU contribution
No data
Address
FRANKFURTER STRASSE 250
64293 Darmstadt
64293 Darmstadt
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Region
Hessen
Darmstadt
Darmstadt, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ninog Péresse (Ms)
Links
Total cost
No data
NOVO NORDISK A/S
Denmark
EU contribution
No data
Address
NOVO ALLE 1
2880 Bagsvaerd
2880 Bagsvaerd
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Region
Danmark
Hovedstaden
Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jorgen Dirach (Dr)
Links
Total cost
No data
ORION OYJ
Finland
EU contribution
No data
Address
ORIONINTIE 1
02200 Espoo
02200 Espoo
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Region
Manner-Suomi
Helsinki-Uusimaa
Helsinki-Uusimaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kimmo Norrena (Legal counsel)
Links
Total cost
No data
PFIZER LIMITED
United Kingdom
EU contribution
No data
Address
RAMSGATE ROAD
CT13 9NJ Sandwich
CT13 9NJ Sandwich
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Region
South East (England)
Kent
East Kent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hannah Hurst (Mrs)
Links
Total cost
No data
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
No data
Address
82 AVENUE RASPAIL
94250 GENTILLY
94250 GENTILLY
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Region
Ile-de-France
Ile-de-France
Val-de-Marne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Monique Guis (Dr (Ph.D MBA))
Links
Total cost
No data
MEDICAL RESEARCH COUNCIL
Participation ended
United Kingdom
EU contribution
€ 32 111,00
Address
20 Park Crescent
W1B 1AL LONDON
W1B 1AL LONDON
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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Jodie Claridge (Mrs)
Links
Total cost
No data
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 431 411,00
Address
EDMOND J SAFRA CAMPUS GIVAT RAM
91904 Jerusalem
91904 Jerusalem
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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hani Ben-Yehuda (Ms.)
Links
Total cost
No data
ASTRAZENECA AB
Sweden
EU contribution
No data
Address
Vastra Maelarhamnen
151 85 Sodertaelje
151 85 Sodertaelje
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Region
Östra Sverige
Stockholm
Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Lindgren (Senior Director)
Links
Total cost
No data
INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS
France
EU contribution
€ 132 600,00
Address
PARC TECHNOLOGIQUE ALATA
60550 Verneuil En Halatte
60550 Verneuil En Halatte
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Region
Hauts-de-France
Picardie
Oise
Activity type
Research Organisations
Administrative Contact
Lydia BOUTIGNY (MME)
Links
Total cost
No data
NEWCELLS BIOTECH LIMITED
United Kingdom
EU contribution
€ 140 987,00
Address
1 TIMES SQUARE SCOTSWOOD ROAD
NE1 4EP Newcastle Upon Tyne
NE1 4EP Newcastle Upon Tyne
See on map
Region
North East (England)
Northumberland and Tyne and Wear
Tyneside
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mike Nicholds (Dr)
Links
Total cost
No data