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Combatting Bacterial Resistance in Europe

Objective

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are around € 1.5 Billion per year in Europe, with an estimated 25,000 deaths (European Center for Disease prevention and Control/European Medicines Agency “time to react”). While the threat of antimicrobial resistance is growing, so are the challenges to bringing forward new therapeutic options for patients infected with resistant organisms. There is a need for a better understanding of how antimicrobial resistance is evolving globally, of what novel molecular mechanisms can be exploited as new forms of antimicrobial therapy and of how to more efficiently develop new treatments so they can be more rapidly brought to patients in need.
The over-arching concept of New Drugs for Bad Bugs (ND4BB) is to create an innovative public-private collaborative partnership that will positively impact all aspects of ARB through the discovery and development of novel agents for the treatment, prevention and management of patients with bacterial infections. COMBACTE is one of the first projects to be launched under this programme with the aim of developing a broad European network of fully capable and Good Clinical Practice (GCP) compliant clinical investigation sites to execute clinical trials enabling the registration of novel agents to be used in the treatment of patients with bacterial infections. The growth and application of the network will be supported with robust microbiologic surveillance data and clinical epidemiologic data. To reduce the time and or cost of clinical development, novel clinical trial designs will be outlined and supported through analysis of publically available and consortium-shared non-clinical and clinical data. In addition to executing the initial set of clinical trials, investigations of patient and pathogen-related biomarkers and the logistical and decision making impact of rapid diagnostics will be conducted.

Call for proposal

IMI-JU-06-2012
See other projects for this call

Coordinator

ASTRAZENECA AB
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Sweden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jörgen Jensen (Project Manager)
Principal investigator
Hasan Jafri (Senior Director, Clinical Research and Development)

Participants (38)

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 30 784 817
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renzo Dettingmeijer (Mr)
CLINIQUE UNIVERSITAIRE SAINT-LUC ASBL
Belgium
EU contribution
€ 719 243
Address
Avenue Hippocrate 10
1200 Bruxelles
Activity type
Other
Administrative Contact
Renaud Mazy (Mr)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 2 428 336
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Petra Schreiner-Kaub (-)
Centre hospitalier universitaire de Limoges
France
EU contribution
€ 48 977 229
Address
Avenue Martin-luther-king 2
87000 Limoges
Activity type
Research Organisations
Administrative Contact
Xavier FRETILLE (Mr)
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Spain
EU contribution
€ 862 572
Address
C Rossello 132 Planta 05
08036 Barcelona
Activity type
Research Organisations
Administrative Contact
Samantha Mardell (Ms)
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON

Participation ended

France
EU contribution
€ 4 380
Address
Place Saint Jacques 2
25030 Besancon Cedex
Activity type
Research Organisations
Administrative Contact
Sophie DEPIERRE (Mrs)
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 1 762 638
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
Administrative Contact
Michael Strätz (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 895 653
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Muriel BOUAS (Mrs)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 8 369 379
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Mrs)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 5 167 190
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephan HARBARTH (Prof.)
JULIUS CLINICAL RESEARCH BV
Netherlands
EU contribution
€ 1 567 067
Address
Broederplein 41-43
3703 CD Zeist
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Beekman (MSc)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 509 217
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jürgen Dreyer (Mr.)
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Participation ended

Switzerland
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Marie-Christine Francioli (Mrs)
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maarten van Langen (Mr.)
NORTH BRISTOL NATIONAL HEALTH SERVICE TRUST
United Kingdom
EU contribution
€ 1 184 970
Address
Southmead Hospital, Southmead Road, Westbury On Trym
BS10 5NB Bristol
Activity type
Research Organisations
Administrative Contact
Alasdair MacGowan (Professor)
UNIVERSITE JOSEPH FOURIER GRENOBLE 1

Participation ended

France
EU contribution
€ 5 918
Address
Avenue Centrale, Domaine Universitaire 621
38041 Grenoble
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Brambilla (Directeur de Laboratoire)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sally Miles (-)
JANSSEN PHARMACEUTICA NV
Belgium
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Celine Van den Broeke (Ms)
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 1 179 018
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Virginia Nieto (Ms.)
CHU de Pointe-à-Pitre
France
EU contribution
€ 39 614
Address
Route De Chauvel
97159 Pointe-à-Pitre Pointe-à-pitre
Administrative Contact
Chantal LERUS (Mme)
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 57 934
Address
Campus Valla
581 83 Linkoping
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gunilla Avefeldt (Mrs)
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 57 934
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Sfikopoulos (Professor)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 1 018 710
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gisela Bauer-Haffter (Biologist)
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 870 128
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Völker (Dr.)
UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 858 140
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javier Olaiz (Dr)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 1 136 553
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Huizer (Mr.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 174 934
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Pastora Martinez Samper (Dr.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 228 934
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Antonio Portolés Pérez (Mr)
THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV
Israel
EU contribution
€ 57 934
Address
Weizmann Street 6
64239 Tel Aviv
Activity type
Research Organisations
Administrative Contact
Michal Roll (Dr)
INSTITUTO NACIONAL DE SAUDE DR. RICARDO JORGE
Portugal
EU contribution
€ 57 934
Address
Avenida Padre Cruz
1649-016 Lisboa
Activity type
Research Organisations
Administrative Contact
Maria Manuela Carvalho (Doctor)
AO Documentation and Publishing Foundation, Clinical Investigation and Documentation
Switzerland
EU contribution
€ 57 934
Address
Clavadelerstrasse
7270 Davos
Activity type
Research Organisations
Administrative Contact
Virginie Schubert (Mrs.)
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Italy
EU contribution
€ 57 934
Address
Via Francesco Sforza 28
20122 Milano
Activity type
Other
Administrative Contact
MANUELA MARTORANA (MRS)
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Address
5 Rue Watt
75013 Paris
Activity type
Research Organisations
Administrative Contact
Alicja Szofer-Araya (Mrs)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 240 766
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kelly Turner (Scientific Manager)
DA VOLTERRA SAS
France
Address
Rue De Charonne 172 Le Dorian Batiment B
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pierre-Alain BANDINELLI (Mr)
The Medicines Company
United States
Address
Sylvan Way
07054 Parsippany
Administrative Contact
Michelle Linfesty (Senior Director, Program Management)
PFIZER LIMITED
United Kingdom
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hanah Hurst (Mrs)
EUROPEAN FORUM FOR GOOD CLINICAL PRACTICE
Belgium
EU contribution
€ 100 000
Address
Rue De Washington 40
1050 Brussels
Activity type
Other
Administrative Contact
Fanny Senez (Mrs)