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Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies

Objective

The current healthcare systems are built around the traditional paradigm of patients suffering from a single acute illness. They are therefore largely unprepared to face the increasing demands for health services arising from the expansion of an older population with specific medical needs related to multiple chronic disorders. As a consequence, the medical conditions of a large and growing segment of the older European population are not efficiently managed by the available healthcare services. Among these conditions, the geriatric syndrome of frailty has emerged as a significant public health priority. It is defined as a multidimensional condition characterised by decreased reserve and diminished resistance to stressors. Such extreme vulnerability exposes the older individual to an increased risk of morbidity, disability, inappropriate healthcare use, institutionalization, poor quality of life, and death. Early detection and prevention of frailty are thus crucial to impede its progression and the development of its detrimental clinical consequences, while ensuring sustainability of healthcare systems of the Member States. Unfortunately, to date, no healthcare programs or pharmacological treatments are available for frail older people. This is largely due to the lack of a precise, universal definition of frailty, linked in turn to the multidimensional nature of the condition. Eventually, the existing gaps in knowledge are reflected by the absence of effective interventions. Such a barrier may be overcome by developing and validating a robust conceptual framework to achieve a practical operationalisation of frailty. This should precisely define its pathophysiological and clinical foundations, to assist in the design and implementation of specific interventions aimed at restoring robustness and delaying the onset of adverse outcomes. The present “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project is specifically designed to overcome the existing barriers for an efficient public health intervention against frailty, and promote the implementation of successful aging strategies across Europe.
To reach such an ambitious goal, the actions of the SPRINTT Consortium are directed towards the achievement of a consensus among academia, regulators, industry (pharmaceutical and medical devices), and patients’ representatives over
(1) clear operationalisation of the presently vague concept of frailty;
(2) identification of a target population with unmet medical needs;
(3) evaluation and validation of methodologies for implementing preventive and therapeutic strategies among frail elders at risk of disability in the European Union;
(4) definition of an experimental setting as a template for regulatory purposes and pharmaceutical investigations;
(5) identification of biomarkers and health technology solutions to be implemented into clinical practice.
Thus, the project is expected to pursue all the research deliverables described in nine work-packages.
The SPRINTT project proposes a novel operationalisation of physical frailty recognising sarcopenia as its central biological substrate. This approach is based on the fact that the physical frailty phenotype overlaps substantially with sarcopenia. Indeed, many of the adverse outcomes of frailty are probably mediated by sarcopenia, which may therefore represent both the biological substrate for the development of physical frailty and the pathway through which the negative health outcomes of frailty ensue. Although physical frailty encompasses only a part of the frailty spectrum, the identification of a definite biological basis (i.e. skeletal muscle decline and loss of mobility function) opens new venues for the development of interventions to slow or reverse the progression of this condition. It is noteworthy that all of the components characterising the Physical Frailty and Sarcopenia (PF&S) model are measurable and qua

Call for proposal

IMI-JU-09-2013
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Coordinator

SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
Address
Pierre Brossolette 1
91380 Chilly Mazarin
France

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Participants (28)

UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 4 331 715
Address
Largo Gemelli 1
20123 Milano

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Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
France
EU contribution
€ 2 247 516
Address
Rue Viguerie 2 Hotel Dieu Saint Jacques
31052 Toulouse Cedex 3

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Activity type
Higher or Secondary Education Establishments
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 757 192
Address
Ovocny Trh 560/5
116 36 Praha 1

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Activity type
Higher or Secondary Education Establishments
ROESSINGH RESEARCH AND DEVELOPMENT BV
Netherlands
EU contribution
€ 200 046
Address
Roessinghsbleekweg 33
7522 AH Enschede

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 1 113 795
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto

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Activity type
Higher or Secondary Education Establishments
CARETEK SRL
Italy
EU contribution
€ 2 450 000
Address
Via Pio Vii 127
10127 Torino

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU-Open S.R.L.
Italy
EU contribution
€ 501 841
Address
Via Marconi
37040 Veronella (Vr)

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SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 2 146 723
Address
Plaza Carlos Trias Bertran 7
28020 Madrid

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Université Paris Descartes
France
EU contribution
€ 368 980
Address
Rue De L'ecole De Médecine
75270 cedex 06 Paris

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Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 253 290
Address
Piazza San Marco 4
50121 Florence

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Activity type
Higher or Secondary Education Establishments
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany
EU contribution
€ 1 417 794
Address
Schlossplatz 4
91054 Erlangen

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Activity type
Higher or Secondary Education Establishments
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 867 536
Address
Ul. Golebia 24
31-007 Krakow

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Higher or Secondary Education Establishments
ISTITUTO NAZIONALE DI RIPOSO E CURA PER ANZIANI INRCA
Italy
EU contribution
€ 1 670 125
Address
Via Santa Margherita 5
60124 Ancona

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Activity type
Research Organisations
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS
France
Address
Rue Carnot 50
92284 Courbevoie

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
Address
Lichtstrasse 35
4056 Basel

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELI LILLY AND COMPANY LTD

Participation ended

United Kingdom
Address
Lilly House Basingview
RG21 4FA Basingstoke

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 1 513 500
Address
Robert-koch-strasse 40
37075 Goettingen

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Activity type
Higher or Secondary Education Establishments
Niche Science & Technology Ltd

Participation ended

United Kingdom
Address
Wolsey Drive
KT2 5DW Kingston-upon-thames

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DIABETES FRAIL LIMITED
United Kingdom
EU contribution
€ 1 388 298
Address
Oakmoore Court 11 C Kingswood Road Hapmton Lovett
WR9 0QH Droitwitch

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Activity type
Research Organisations
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 704 088
Address
Minderbroedersberg 4
6200 MD Maastricht

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Activity type
Higher or Secondary Education Establishments
ASTON UNIVERSITY

Participation ended

United Kingdom
EU contribution
€ 715 300
Address
Aston Triangle
B4 7ET Birmingham

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Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PARMA
Italy
EU contribution
€ 650 000
Address
Via Universita 12
43100 Parma

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Activity type
Higher or Secondary Education Establishments
HASKOLI ISLANDS
Iceland
EU contribution
€ 349 650
Address
Saemundargotu 2
101 Reykjavik

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Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 352 050
Address
Auenbruggerplatz 2
8036 Graz

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Activity type
Higher or Secondary Education Establishments
ASTELLAS PHARMA EUROPE BV
Netherlands
Address
Sylviusweg 84
2333 BE Leiden

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Biophytis SA
France
Address
Avenue De L'opera
75001 Paris

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BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Address
Binger Strasse
55218 Ingelheim

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)