Objective The problem: finding the right patient for the right treatmentDespite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have de-emphasized or even abandoned OA drug development due to perceived hurdles. Crucial in this is the lack of appropriate outcome measures that can robustly identify patient benefit from a specific therapy. The lack of specific and sensitive endpoints to differentiate between responders and non-responders both at the level of pain and tissue structure modification (disease modifying OA drug: DMOAD) has led to trials that included hundreds of patients in each arm with at least 3-years follow-up. Even despite these enormous trials, EMA and FDA have not approved any DMOAD yet. There is a general lack of understanding OA pathogenesis, which appears rather variable and likely reflecting different phenotypes with fundamental differences in disease aetiology, tissue alterations, clinical manifestations (pain/mobility) and disease progression. Although the current mind-set for drug treatment in the field is moving to a more personalized medicine and patient stratification approach, there are no accepted methods or guidelines to classify patients according to their prognosis and differentiate between subsets in terms of diagnosis methodology and treatment plan. The APPROACH consortium brings together a competent and multidisciplinary group of stakeholders that will setup – for the first time – a longitudinal cohort based on highly innovative stratification methods that identifies different OA phenotypes and subsequently develop guidelines for differentially diagnosing the right patient for the right treatment.The stratified medicine APPROACH The APPROACH consortium brings together a unique complimentary set of skills to develop, validate and link biomarkers with biological processes and clinical end points in OA patient subsets. This will support future regulatory qualification and guide clinical trials for relevant endpoint validation, thereby paving the road for stratified or personalized medicine. This leads to the following overall objectives of the consortium:- Implement and establish a new, integrated and comprehensive database platform of existing data from partners that will be extended with newly collected longitudinal data, incorporating novel high quality biomarkers.- Define subsets of (phenotypically) different patients in both the existing cohorts as well as (later) in the new longitudinal extension cohorts and subsequently identify the “right patient” to treat for each subset/phenotype via innovative stratification techniques. - Optimize, introduce and validate the next generation imaging methodologies (modality + post-processing), human motion analysis and biochemical assays to enable more efficient and reliable diagnoses and treatment of OA patients. - Identify mechanistic targets for patient subsets, create prediction models and establish guidelines for a DMOAD development that forms the roadmap for OA.APPROACH: a tri-partite partnership between relevant stakeholdersThe ambitious objectives of the APPROACH consortium require the mobilization of a broad set of skills and extensive expertise, from academics, clinicians and the private sector. The APPROACH consortium brings together a strong tri-partite team from European clinical centers (cohorts), basic research institutes (state-of-the-art tools) and SME/Industry (certified tool analyses and logistics) which also collaborate with large US-based OAI and MOST cohorts. This group is engaged with end users in hospitals and patient advocacy groups actively involved in OA awareness, fundraising and research support. The consortium crosses barriers and enables inter-sectorial collaborations that bring together all the expertise and knowledge in one place, where the information can be seamlessly integrated and, as such, contributes to innovative stratification and personalized diagnostic methods Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencescomputer and information sciencesdatabasesmedical and health scienceshealth sciencespersonalized medicine Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-11-2013-01 - Applied Public-Private Research Enabling Osteoarthritis Clinical Headway (APPROACH) Call for proposal IMI-JU-11-2013 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. Address Great west road 980 TW89GS Brentford United Kingdom See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sally Miles (Ms) Principal investigator Jonathan Larkin (-) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (24) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 2 919 900,00 Address Heidelberglaan 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Antoinette van der Linden-Gruntjes (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data STICHTING LYGATURE Netherlands EU contribution € 695 000,00 Address Jaarbeursplein 6 3521 AL Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Other Administrative Contact Leonie Hussaarts (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MAX IV Laboratory, Lund University Sweden EU contribution € 162 500,00 Address Paradisgatan 5c 22100 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact Susanne Bauer (PhD) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 190 000,00 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Christian Herold (O. Univ.-Prof., Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom EU contribution € 550 000,00 Address Kings gate NE1 7RU Newcastle upon tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact FIONA AIREY (MRS) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG Germany EU contribution € 75 000,00 Address Schlossplatz 4 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Franziska Müller (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITATSKLINIKUM ERLANGEN Germany EU contribution € 35 000,00 Address Maximiliansplatz 2 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Katrin Faber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Artialis SA Belgium EU contribution € 250 000,00 Address Avenue de l'hôpital 4000 Liège (sart-tilman) See on map Administrative Contact Jeannette Chignesse (Management assistant) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data HEMICS BV Netherlands EU contribution € 200 000,00 Address Kennedyplein 201 5611 ZT Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Wouter Rensen (Dr) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF LEEDS United Kingdom EU contribution € 150 000,00 Address Woodhouse lane LS2 9JT Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Higher or Secondary Education Establishments Administrative Contact Martin Hamilton (Mr) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Stichting ReumaNederland Netherlands EU contribution € 112 500,00 Address Admiraal helfrichstraat 1 1056 AA Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Other Administrative Contact Wilma Kop (N/A) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 701 010,00 Address Albinusdreef 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Marieke Bax (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF SURREY United Kingdom EU contribution € 400 000,00 Address Stag hill GU2 7XH Guildford See on map Region South East (England) Surrey, East and West Sussex West Surrey Activity type Higher or Secondary Education Establishments Administrative Contact Maria Sega-Buhalis (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SERVIZO GALEGO DE SAUDE Spain EU contribution € 458 000,00 Address Edificio administrativo san lázaro 15703 Santiago de compostela See on map Region Noroeste Galicia A Coruña Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact SANTIAGO PEREZ CACHAFEIRO (MD) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 178 050,00 Address 55 boulevard diderot 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Patrica Schott (Madame) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DIAKONHJEMMET SYKEHUS AS Norway EU contribution € 163 040,00 Address Diakonveien 14 0319 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Research Organisations Administrative Contact Ida Kristin Haugen (Md, PhD) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Immunodiagnostic Systems Holdings PLC United Kingdom EU contribution € 0,00 Address Boldon business park NE35 9PD Boldon See on map Administrative Contact Dagmar Kasper (Dr) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data European Technology for Business Ltd United Kingdom EU contribution € 185 000,00 Address Rothesay rd LU1 1QZ Luton See on map Administrative Contact Denis Hodgins (Mr) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Arthritis Research UK United Kingdom EU contribution € 0,00 Address St mary's gate ST41 7TD Chesterfield See on map Administrative Contact Sarah Rudkin (Dr) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS France EU contribution € 0,00 Address Rue carnot 50 92284 Courbevoie See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marie DUVICQ (Mme) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Merck KGaA Germany EU contribution € 0,00 Address Frankfurter strasse 250 64293 Darmstadt See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ninog Peresse (Scientific Innovation and Partnerships) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S Denmark EU contribution € 0,00 Address Herlev hovedgade 207 2730 Helev See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kristina Adrian König (Legal Counsel) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 75 000,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Patrick Mounaud (Mr) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ABBVIE INC United States EU contribution € 0,00 Address North waukegan road 1 60064 North chicago il See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Samantha Zappia (M.S.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data