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Development of a Prophylactic Ebola Vaccine Using an Heterologous Prime-Boost Regimen – Sofia ref.: 115854

Deliverables

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Publications

Assessing the performance of real-time epidemic forecasts: A case study of Ebola in the Western Area region of Sierra Leone, 2014-15

Author(s): Sebastian Funk, Anton Camacho, Adam J. Kucharski, Rachel Lowe, Rosalind M. Eggo, W. John Edmunds
Published in: PLOS Computational Biology, Issue 15/2, 2019, Page(s) e1006785, ISSN 1553-7358
DOI: 10.1371/journal.pcbi.1006785

An online decision tree for vaccine efficacy trial design during infectious disease epidemics: The InterVax-Tool

Author(s): Steven E. Bellan, Rosalind M. Eggo, Pierre-Stéphane Gsell, Adam J. Kucharski, Natalie E. Dean, Richard Donohue, Matt Zook, W. John Edmunds, Frank Odhiambo, Ira M. Longini, Marc Brisson, Barbara E. Mahon, Ana Maria Henao-Restrepo
Published in: Vaccine, Issue 37/31, 2019, Page(s) 4376-4381, ISSN 0264-410X
DOI: 10.1016/j.vaccine.2019.06.019

Comparative ethnographies of medical research: materiality, social relations, citizenship and hope in Tanzania and Sierra Leone

Author(s): Shelley Lees, Luisa Enria
Published in: International Health, Issue 12/6, 2020, Page(s) 575-583, ISSN 1876-3413
DOI: 10.1093/inthealth/ihaa071

Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate

Author(s): Ramon Roozendaal, Jenny Hendriks, Thierry van Effelterre, Bart Spiessens, Liesbeth Dekking, Laura Solforosi, Dominika Czapska-Casey, Viki Bockstal, Jeroen Stoop, Daniel Splinter, Sarah Janssen, Ben van Baelen, Nadia Verbruggen, Jan Serroyen, Eline Dekeyster, Ariane Volkmann, Yvonne Wollmann, Ricardo Carrion, Luis D. Giavedoni, Cynthia Robinson, Maarten Leyssen, Macaya Douoguih, Kerstin Luhn, Maria
Published in: npj Vaccines, Issue 5/1, 2020, ISSN 2059-0105
DOI: 10.1038/s41541-020-00261-9

Implementation of accelerated research: strategies for implementation as applied in a phase 1 Ad26.ZEBOV, MVA-BN-Filo two-dose Ebola vaccine clinical trial in Uganda

Author(s): Jonathan Kitonsa, Abu-Baker Ggayi, Zacchaeus Anywaine, Eva Kisaakye, Laura Nsangi, Vincent Basajja, Mary Nyantaro, Deborah Watson-Jones, Georgi Shukarev, Ine Ilsbroux, Cynthia Robinson, Pontiano Kaleebu
Published in: Global Health Action, Issue 13/1, 2020, Page(s) 1829829, ISSN 1654-9716
DOI: 10.1080/16549716.2020.1829829

Estimating the probability of demonstrating vaccine efficacy in the declining Ebola epidemic: a Bayesian modelling approach

Author(s): Anton Camacho, Rosalind M Eggo, Sebastian Funk, Conall H Watson, Adam J Kucharski, W John Edmunds
Published in: BMJ Open, Issue 5/12, 2015, Page(s) e009346, ISSN 2044-6055
DOI: 10.1136/bmjopen-2015-009346

Duration of Ebola virus RNA persistence in semen of survivors: population-level estimates and projections

Author(s): Rosalind M Eggo, Conall H Watson, Anton Camacho, Adam J Kucharski, Sebastian Funk, W John Edmunds
Published in: Eurosurveillance, Issue 20/48, 2015, Page(s) Volume 20, 2015, ISSN 1025-496X
DOI: 10.2807/1560-7917.ES.2015.20.48.30083

Effectiveness of Ring Vaccination as Control Strategy for Ebola Virus Disease

Author(s): Adam J. Kucharski, Rosalind M. Eggo, Conall H. Watson, Anton Camacho, Sebastian Funk, W. John Edmunds
Published in: Emerging Infectious Diseases, Issue 22/1, 2016, Page(s) 105-108, ISSN 1080-6040
DOI: 10.3201/eid2201.151410

A two-dose heterologous prime-boost vaccine regimen eliciting sustained immune responses to Ebola Zaire could support a preventive strategy for future outbreaks

Author(s): Georgi Shukarev, Benoit Callendret, Kerstin Luhn, Macaya Douoguih
Published in: Human Vaccines & Immunotherapeutics, Issue 13/2, 2017, Page(s) 266-270, ISSN 2164-5515
DOI: 10.1080/21645515.2017.1264755

Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study

Author(s): Daouda Sissoko, Sophie Duraffour, Romy Kerber, Jacques Seraphin Kolie, Abdoul Habib Beavogui, Alseny-Modet Camara, Géraldine Colin, Toni Rieger, Lisa Oestereich, Bernadett Pályi, Stephanie Wurr, Jeremie Guedj, Thi Huyen Tram Nguyen, Rosalind M Eggo, Conall H Watson, W John Edmunds, Joseph Akoi Bore, Fara Raymond Koundouno, Mar Cabeza-Cabrerizo, Lisa L Carter, Liana Eleni Kafetzopoulou, Eeva Kuis
Published in: The Lancet Global Health, Issue 5/1, 2017, Page(s) e80-e88, ISSN 2214-109X
DOI: 10.1016/S2214-109X(16)30243-1

Power, fairness and trust: understanding and engaging with vaccine trial participants and communities in the setting up the EBOVAC-Salone vaccine trial in Sierra Leone

Author(s): Luisa Enria, Shelley Lees, Elizabeth Smout, Thomas Mooney, Angus F. Tengbeh, Bailah Leigh, Brian Greenwood, Deborah Watson-Jones, Heidi Larson
Published in: BMC Public Health, Issue 16/1, 2016, ISSN 1471-2458
DOI: 10.1186/s12889-016-3799-x

Real-time forecasting of infectious disease dynamics with a stochastic semi-mechanistic model

Author(s): Sebastian Funk, Anton Camacho, Adam J. Kucharski, Rosalind M. Eggo, W. John Edmunds
Published in: Epidemics, Issue 22, 2018, Page(s) 56-61, ISSN 1755-4365
DOI: 10.1016/j.epidem.2016.11.003

Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines

Author(s): Iain D. Milligan, Malick M. Gibani, Richard Sewell, Elizabeth A. Clutterbuck, Danielle Campbell, Emma Plested, Elizabeth Nuthall, Merryn Voysey, Laura Silva-Reyes, M. Juliana McElrath, Stephen C. De Rosa, Nicole Frahm, Kristen W. Cohen, Georgi Shukarev, Nicola Orzabal, Wilbert van Duijnhoven, Carla Truyers, Nora Bachmayer, Daniel Splinter, Nathaly Samy, Maria Grazia Pau, Hanneke Schuitemaker, Kers
Published in: JAMA, Issue 315/15, 2016, Page(s) 1610, ISSN 0098-7484
DOI: 10.1001/jama.2016.4218

Simulation-guided phase 3 trial design to evaluate vaccine effectiveness to prevent Ebola virus disease infection: Statistical considerations, design rationale, and challenges

Author(s): An Vandebosch, Robin Mogg, Nele Goeyvaerts, Carla Truyers, Brian Greenwood, Debby Watson-Jones, Guillermo Herrera-Taracena, Wim Parys, Tony Vangeneugden
Published in: Clinical Trials: Journal of the Society for Clinical Trials, Issue 13/1, 2016, Page(s) 57-65, ISSN 1740-7745
DOI: 10.1177/1740774515621059

Real-time dynamic modelling for the design of a cluster-randomized phase 3 Ebola vaccine trial in Sierra Leone

Author(s): A. Camacho, R.M. Eggo, N. Goeyvaerts, A. Vandebosch, R. Mogg, S. Funk, A.J. Kucharski, C.H. Watson, T. Vangeneugden, W.J. Edmunds
Published in: Vaccine, Issue 35/4, 2017, Page(s) 544-551, ISSN 0264-410X
DOI: 10.1016/j.vaccine.2016.12.019

Immune Responses to Novel Adenovirus Type 26 and Modified Vaccinia Virus Ankara–Vectored Ebola Vaccines at 1 Year

Author(s): Rebecca L. Winslow, Iain D. Milligan, Merryn Voysey, Kerstin Luhn, Georgi Shukarev, Macaya Douoguih, Matthew D. Snape
Published in: JAMA, Issue 317/10, 2017, Page(s) 1075, ISSN 0098-7484
DOI: 10.1001/jama.2016.20644

“We are the heroes because we are ready to die for this country”: Participants' decision-making and grounded ethics in an Ebola vaccine clinical trial

Author(s): Angus Fayia Tengbeh, Luisa Enria, Elizabeth Smout, Thomas Mooney, Mike Callaghan, David Ishola, Bailah Leigh, Deborah Watson-Jones, Brian Greenwood, Heidi Larson, Shelley Lees
Published in: Social Science & Medicine, Issue 203, 2018, Page(s) 35-42, ISSN 0277-9536
DOI: 10.1016/j.socscimed.2018.03.008

Citizens, dependents, sons of the soil: Defining political subjectivities through encounters with biomedicine during the Ebola epidemic in Sierra Leone

Author(s): Luisa Enria, Shelley Lees
Published in: Medicine Anthropology Theory | An open-access journal in the anthropology of health, illness, and medicine, Issue 5/4, 2018, ISSN 2405-691X
DOI: 10.17157/mat.5.4.512

Stability and suitability for storage and distribution of Ad26.ZEBOV/MVA-BN®-Filo heterologous prime-boost Ebola vaccine

Author(s): Martinus A.H. Capelle, Lara Babich, J.P. Els van Deventer-Troost, Doris Salerno, Kelly Krijgsman, Ulrike Dirmeier, Britt Raaby, Janik Adriaansen
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 129, 2018, Page(s) 215-221, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2018.06.001

EBOVAC-Salone: Lessons learned from implementing an Ebola vaccine trial in an Ebola-affected country

Author(s): Thomas Mooney, Elizabeth Smout, Bailah Leigh, Brian Greenwood, Luisa Enria, David Ishola, Daniela Manno, Mohamed Samai, Macaya Douoguih, Deborah Watson-Jones
Published in: Clinical Trials, Issue 15/5, 2018, Page(s) 436-443, ISSN 1740-7745
DOI: 10.1177/1740774518780678

Dynamics of the Humoral Immune Response to a Prime-Boost Ebola Vaccine: Quantification and Sources of Variation

Author(s): Chloé Pasin, Irene Balelli, Thierry Van Effelterre, Viki Bockstal, Laura Solforosi, Mélanie Prague, Macaya Douoguih, Rodolphe Thiébaut
Published in: Journal of Virology, Issue 93/18, 2019, ISSN 0022-538X
DOI: 10.1128/jvi.00579-19

Safety and Immunogenicity of a 2-Dose Heterologous Vaccine Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Nairobi, Kenya

Author(s): Gaudensia Mutua, Omu Anzala, Kerstin Luhn, Cynthia Robinson, Viki Bockstal, Dickson Anumendem, Macaya Douoguih
Published in: The Journal of Infectious Diseases, Issue 220/1, 2019, Page(s) 57-67, ISSN 0022-1899
DOI: 10.1093/infdis/jiz071

Health care worker vaccination against Ebola: Vaccine acceptance and employment duration in Sierra Leone

Author(s): Mario Jendrossek, W. John Edmunds, Hana Rohan, Samuel Clifford, Thomas A. Mooney, Rosalind M. Eggo
Published in: Vaccine, Issue 37/8, 2019, Page(s) 1101-1108, ISSN 0264-410X
DOI: 10.1016/j.vaccine.2018.12.060

Determinants of Transmission Risk During the Late Stage of the West African Ebola Epidemic

Author(s): Alexis Robert, W John Edmunds, Conall H Watson, Ana Maria Henao-Restrepo, Pierre-Stéphane Gsell, Elizabeth Williamson, Ira M Longini, Keïta Sakoba, Adam J Kucharski, Alhassane Touré, Sévérine Danmadji Nadlaou, Boubacar Diallo, Mamamdou Saidou Barry, Thierno Oumar Fofana, Louceny Camara, Ibrahima Lansana Kaba, Lansana Sylla, Mohamed Lamine Diaby, Ousmane Soumah, Abdourahime Diallo, Amadou Niar
Published in: American Journal of Epidemiology, Issue 188/7, 2019, Page(s) 1319-1327, ISSN 0002-9262
DOI: 10.1093/aje/kwz090

Safety and Immunogenicity of a 2-Dose Heterologous Vaccination Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Uganda and Tanzania

Author(s): Zacchaeus Anywaine, Hilary Whitworth, Pontiano Kaleebu, George Praygod, Georgi Shukarev, Daniela Manno, Saidi Kapiga, Heiner Grosskurth, Samuel Kalluvya, Viki Bockstal, Dickson Anumendem, Kerstin Luhn, Cynthia Robinson, Macaya Douoguih, Deborah Watson-Jones
Published in: The Journal of Infectious Diseases, Issue 220/1, 2019, Page(s) 46-56, ISSN 0022-1899
DOI: 10.1093/infdis/jiz070

Control of Ebola virus disease outbreaks: Comparison of health care worker-targeted and community vaccination strategies

Author(s): Alexis Robert, Anton Camacho, W. John Edmunds, Marc Baguelin, Jean-Jacques Muyembe Tamfum, Alicia Rosello, Sakoba Kéïta, Rosalind M. Eggo
Published in: Epidemics, Issue 27, 2019, Page(s) 106-114, ISSN 1755-4365
DOI: 10.1016/j.epidem.2019.03.001