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Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952

Objective

Beta-amyloid (β-amyloid) deposition is considered to be a necessary - but not sufficient - step on the path towards Alzheimer’s disease (AD). Depiction of brain β-amyloid in vivo can support an early diagnosis, and even provide an opportunity for consider secondary prevention of AD. Currently, however, the value of β-amyloid PET remains elusive, reason why this procedure is typically not reimbursed.

Understanding the value of imaging of β-amyloid using positron emission tomography (PET) provides a unique opportunity to achieve 3 major goals: 1) improve the diagnostic workup of patients suspected of AD and their management; 2) stratify risk for AD and select homogenous groups for intervention; and 3) quantify treatment effects more accurately.

AMYPAD will address the above objectives by studying the onset, dynamics, and clinical relevance of brain β-amyloid
in the spectrum from normal aging to preclinical and prodromal AD. We will use β-amyloid-PET in an unprecedented large number of subjects (n=4000) from population studies, as well as memory clinics cohorts, with repeat imaging in up to 2000. In close collaboration with EPAD (www.ep-ad.org) the cohorts will be followed with to determine (surrogate) outcomes of cognitive decline and neurodegeneration.

Lead from VU-VUmc, the Consortium brings together a word-class team of highly synergistic partners from across Europe constituting a highly experienced and efficient β-amyloid imaging network including the most active European PET sites, to ensure effective tracer delivery, access to patients and expertise to technical knowledge and disease modelling.

AMYPAD will establish the true value of β-amyloid PET across the severity range of AD. Patients and clinicians will benefit from better and cost-effective diagnostic procedures and management, while academics and industry will benefit from better disease understanding, clear reimbursement strategy and more rationale and efficient clinical trial design.

Coordinator

STICHTING VUMC
Net EU contribution
€ 3 753 529,00
Address
De Boelelaan 1117
1081 HV Amsterdam
Netherlands
Activity type
Research Organisations
Non-EU contribution
€ 1 330 797,85

Participants (16)

THE UNIVERSITY OF EDINBURGH
United Kingdom
Net EU contribution
€ 734 617,00
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER
Spain
Net EU contribution
€ 1 887 500,00
Address
Calle Wellington 30
08005 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 0,00
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 3 095 452,00
Region
Schweiz/Suisse/Svizzera Région lémanique Genève
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 428 158,00
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

REGION STOCKHOLM
Sweden
Net EU contribution
€ 325 217,00
Address
Hantverkargatan 45
104 22 Stockholm
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
IXICO TECHNOLOGIES LIMITED
United Kingdom
Net EU contribution
€ 1 196 136,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
4Th Floor Griffin Court 15 Long Lane
EC1A 9PN London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
London Inner London — West Camden and City of London
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
France
Net EU contribution
€ 1 061 578,00
Address
Rue Viguerie 2 Hotel Dieu Saint Jacques
31052 Toulouse Cedex 3
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 960 526,00
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
London Inner London — West Camden and City of London
ALZHEIMER EUROPE
Luxembourg
Net EU contribution
€ 222 750,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Rue Dicks 14
1417 Luxembourg
Activity type
Other
Non-EU contribution
€ 0,00
SYNAPSE RESEARCH MANAGEMENT PARTNERS SL
Spain
Net EU contribution
€ 557 750,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Calle Velazquez 94 Planta 1
28006 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Comunidad de Madrid Comunidad de Madrid Madrid
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
Net EU contribution
€ 697 125,00
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
GE HEALTHCARE LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Amersham Place
HP7 9NA Little Chalfont
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 5 807 000,00
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Buckinghamshire CC
 
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 094 202,15
LIFE MOLECULAR IMAGING LTD
United Kingdom
Net EU contribution
€ 0,00
Address
Iceni Centre, Warwick Technology Park
CV34 6DA Warwick
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 4 001 950,00
Region
West Midlands (England) Herefordshire, Worcestershire and Warwickshire Warwickshire
 
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
Net EU contribution
€ 0,00
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 175 000,00
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Oost-Nederland Gelderland Arnhem/Nijmegen