Objective
Atherosclerosis accounts for the majority of brain infarctions and it is a chronic process that is converted into an acute syndrome when a lesion ruptures and triggers thrombosis. The risk profile of advanced atherogenesis is signalled by markers of enhanced prothrombotic capacity, attenuated fibrinolysis and defective coagulation. Patients with more than 3 procoagulant risk conditions have carotid stenosis or show progression of pre-existing stenosis during a 5-year period. Inflammation, local fibrinogenesis /fibrinolysis and intraplaque remodelling significantly contributes towards atherosclerotic plaque rupture.
Molecular mechanisms leading to the above processes remains controversial. Because risk factor control is not enough to detain the atherosclerotic process, we aim to search of new genes that may be differentially expressed by advanced carotid lesion. Using PALM micro-laser technology we will be able to differentiate areas and also individual cells within the plaque over-expressing studied genes. Results obtained will be compared to corresponding plaque protein expression and related plasma circulating molecules and studied biochemical parameters. Patients clinical subgroups will be formed based on symptomatic disease, presence of VRF and plaque stability/histology type.
To identify molecular mechanisms leading to symptomatic carotid disease by studying differential gene expression in the advanced carotid plaque selected genes of interest identified in previous studies will be analysed by RT-PCR: TF, TFP I, MMP-2, MMP-8, MMP-9, COX-2, PLA2, LRP, Caveoline, Bax, Bcl2. Further, gene and protein de-regulation will be examined in serum and tissue specimens. Genes of interest will be selected and their protein expression will be studied in plaque homogenates and selected areas of plaque tissue. We hope to describe the role of identified markers in mediating cellular damage/activation, plaque progression and instability resulting in symptomatic carotid disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine immunology
- natural sciences biological sciences histology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.