Objective A safe and effective vaccine is the only way to stop the spread of HIV, especially in developing countries. Despite enormous efforts of numerous groups no convincing protective vaccine against HIV-1 has been generated so far. We suggest an alternative appr oach in HIV vaccine development: to test virus like particles composed of primary HIV proteins or recombinant proteins with native conformation which are incorporated into liposomes of the size of virions and with a lipid composition similar to the virus m embrane. The aim of the project is to develop this concept from the laboratory to proof-of concept studies in non-human primates. We recently established a novel large scale technology for generation of liposomes with desired properties and within this pro ject will adapt this technology to incorporate HIV-1 proteins into liposomes thereby stabilising their native conformation. Resulting virosomes carrying HIV proteins will be utilised as prophylactic and therapeutic vaccine against HIV-1 infection. Since th is vaccine is cheap to produce, stable and might be administered in a needle free format, this approach ideally meets the specific needs of developing countries. Fields of science medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Keywords HIV vaccine Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-2.3.0-1 - Highly innovative approaches for the development of new interventions for HIV, malaria and tuberculosis Call for proposal FP6-2003-LIFESCIHEALTH-3 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH EU contribution No data Address Nussdorfer Laende 11 VIENNA Austria See on map Links Website Opens in new window Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution No data Address Meyerhofstrasse 1 HEIDELBERG See on map Links Website Opens in new window Total cost No data FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Netherlands EU contribution No data Address Lange Kleiweg 139 RIJSWIJK See on map Links Website Opens in new window Total cost No data UNIVERSITY OF NATURAL RESOURCES AND APPLIED LIFE SCIENCES Austria EU contribution No data Address Muthgasse 18B VIENNA See on map Links Website Opens in new window Total cost No data
