Objective
The interaction of specific biomolecules like endotoxins or certain proteins with organisms can be a major cause of diseases. Prominent examples are pyrogenes - lipopolysacharides (LPS) and lipoteichoic acids (LTA) -, which cause fever in human body and ar e potentially lethal after injection. In some cases the secondary or tertiary structure of proteins is responsible for their biological properties. Important example is PrP (prion). Some contaminated object such as a surface (e.g. medical devices, accessor ies, work surface or tissue) cannot be decontaminated with current sterilisation practices at all or only with inducing major damage to the substrate or tissue itself. An applicable innovative technology for the inactivation of pathogenic biomolecules is, therefore, urgently desired. It is proposed to exploit the feasibility of plasma discharges as decontamination device for pathogenic biomolecules. Emerging species from the plasma discharge interact individually as well as simultaneously with the biomolecu les. It is expected that this reactive particle flux is able to induce alteration and inactivation of biomolecules. This is addressed in a combined approach using low and high pressure plasma discharges. Different characteristic biomolecules are exposed to the plasmas and the changes induced are monitored. In a second step, the inactivation of resistant bacterial endospores is explored. The potential applications are in the field of surface decontamination of medical objects and surfaces as well as control of a biological environment. The results of the research will have also an important impact in the field of security and protection of citizens in front of bioterrorism. For instance, atmospheric plasma sources will be developed and validated to serve as a decontamination device in the field. The processes will also be developed to be applicable on large areas for medical applications
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences political sciences political transitions terrorism
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-NEST-B-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BOCHUM
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.