Objective
Embryomics is devoted to the morphodynamical "reconstruction" of the cell lineage tree underlying the processes of animal embryogenesis. We will design a set of strategies, methods and algorithms to "sequence" the cell lineage tree as a branching process a nnotated in space and time. We view this highly interdisciplinary project as the foundation of a new scientific field that we call Embryomics with a reference to Genomics. In the same sense as Genomics, Embryomics is both a scientific field and a technolog y to gather data with a lot of potential applications. But the Embryomics data is much more 'complex' than a mere DNA sequence as it does not appear as a linear static information in one dimension but as a branching dynamical process displayed in space and time. To deal with this information, we undertake a highly novel and most promising approach based on the strategies of the mammalian visual system. Our goal is to fully reconstruct the dynamics of cell divisions and movements from time-lapse series of hi gh-resolution optical sections obtained by multiphoton laser scanning microscopy throughout embryonic development of live animals. Embryomics will allow the automated tracking of events such as cell division and cell death in live embryos and give us acces s to parameters such as the rate of cell proliferation in time and space. This kind of data is highly relevant to investigate stem cell populations, early steps of cancerogenesis and drug effects in vivo. The post-genomic era needs such a systematic approa ch at the level of the cellular organization to achieve an integrated understanding of biological processes. In addition, through the investigation of four different organisms with key phylogenetic positions, we aim at promoting the use of non-mammalian an imal models. A comparative Embryomics strategy is the best way to evaluate the relevance of animal models, whatever their evolutionary distance to human, for further medical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences developmental biology
- natural sciences physical sciences optics microscopy
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-NEST-B-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.