Objective
Introduciton: Unlike monoclonal antibodies from hybridomas, recombinant antibodies from bacteria usually suffer from poor stability and yield. Due to surface displayed antibody molecules, recombinant antibodies are easily screened, though. (WP1) In order to combine both advantages, we plan to construct a library of >10(+6) different hybridomas by consecutive homologous and specific recombinations, with all of the hybridomas descending from one single cell. Each dell displays >100.000 of "its" specifi c antibody molecules on the cell surface. Therefore, the library should be easily screened fo low to medium affinity human antibodies specific for almost all antigens. (WP2) Antibodies of higher affinities will be generated by the apparatus responsible fo r somatic hypermutations currently being deciphered, whereby FACS-screening offers an especially easy method to compare affinities. (WP3) The ancestor cell line of our antibody library is engineered to emit signals in response to antigen binding, thus a llowing for the labelling detection of antigen-specific antibodies. Outlook: The combined efforts described above might evolve into a method that supersedes the current state of the art in the production of monoclonal antibodies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-NEST-PATH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.