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Radiation exposures at an early age: impact of genotype on breast cancer risk

Objective

The relative risks of breast cancer for women exposed to external radiation in childhood, adolescence and early reproductive years are among the highest known radiation related risks for any cancer type. A number of genes increase breast cancer susceptibility and are known to be involved in detection and repair of radiation-induced DNA damage. DNA repair mechanisms play an important role in the cellular response to radiation exposure and hence on the risk of radiation induced cancer. Mutations or polymorphisms in these genes may therefore render cells more sensitive to radiation-induced cancer. The overall objective of the current contract is to conduct an epidemiological study designed to examine the role of low dose radiation exposure in the aetiology of breast cancer in young women and study its possible interaction with genetic susceptibility. A supplementary objective will be to study the possible modifying effects of other other risk factors for breast cancer, including reproductive factors and cancer therapies other than radiation. Because of the low prevalence of mutation carriers and because of the generally low levels of ionising radiation exposure in the general population, population-based studies of breast cancer risk are unlikely to be informative for this purpose. The current project therefore focuses on the conduct of complementary multi-national nested case-control studies of breast cancer in different populations chosen on the basis of high prevalence of radiation exposure and/or high prevalence of known mutations in susceptibility genes to maximize the power to study the effects of radiation exposure on the risk of breast cancer and its interaction with relatively rare genetic mutations. Overall, it is estimated that approximately 1000 cases of breast cancer and their matched controls from 8 European countries will be included in the case-control studies.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/clinical medicine/cancer/breast cancer
  • /natural sciences/biological sciences/genetics and heredity/mutation

Call for proposal

EURATOMCALL2004-FIXEDDEADLINE
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
Address
150 Cours Albert Thomas
Lyon
France

Participants (11)

CENTRE NATIONAL FRANCOIS BACLESSE
France
Address
Avenue General Harris
PB 5076 Caen
INSTITUT GUSTAVE ROUSSY
France
Address
39 Rue Camille Desmoulins
Villejuif
ISTITUTO GIANNINA GASLINI
Italy
Address
Largo Gerolamo Gaslini 5
Genova
HET NEDERLANDS KANKER INSTITUUT / ANTONI VAN LEEUWENHOEK HOSPITAL
Netherlands
Address
Plesmanlaan 121
Amsterdam
LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5C
P.O.Box 117 Lund
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Exhibition Road, South Kensington Campus
London
INSTITUTE OF CANCER RESEARCH - ROYAL CANCER HOSPITAL
United Kingdom
Address
Old Brompton Road 123
London
UNIVERSITY OF WALES SWANSEA
United Kingdom
Address
Singleton Park
Swansea
THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
UNIVERSITY OF BIRMINGHAM
United Kingdom
Address
Edgbaston
Birmingham
CENTRE RENE HUGUENIN
France
Address
35 Rue Dailly
Saint-cloud