Final Activity Report Summary - THIOCARB (Thiocarboxylic Acid Derivatives: New Tools in Organofluorine Chemistry)
The basic concept of the project THIOCARB was to explore the combination of the specific properties of sulphur, fluorine and silicon to develop an innovative chemistry towards new fluorinated reagents, building blocks and target compounds. The project addressed the investigation of new cascade (domino) reactions based on dithiocarboxylic acid derivatives. The initial idea was to take profit of the ability of the carbon sulphur double bond to add nucleophilic reagents at sulphur (thiophilic addition) in suitable circumstances and to combine this addition with the elimination of a nucleofugal group.
Such a process would lead to a ketene dithioacetal the structure of which depending on both the substrate and the nucleophile.
Another important aspect of the project was the application of the above mentionned strategy in the very important field of organofluorine compounds, in order to have access to original processes and original products.
The presence of fluorine either on the dithiocarboxylic substrate or on the nucleophilic reagent was considered, with two completely different objectives in term of targeted compounds and also in term of applications.
Such a process would lead to a ketene dithioacetal the structure of which depending on both the substrate and the nucleophile.
Another important aspect of the project was the application of the above mentionned strategy in the very important field of organofluorine compounds, in order to have access to original processes and original products.
The presence of fluorine either on the dithiocarboxylic substrate or on the nucleophilic reagent was considered, with two completely different objectives in term of targeted compounds and also in term of applications.