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Third Generation Scaffolds for Tissue Engineering and Regenerative Medicine

Objective

The project proposed is therefore a radically new approach to fabricate safe bioactive materials for tissue engineering and regenerative medicine. We propose to use cells as micro-factories to produce and assemble the molecular components at the nanometer level which is not possible by conventional mechanical engineering. This cellular engineering will be used to produce the supportive structure with desired shape, compliance and mechanical strength at meso- and macroscale levels. We achieve this by engine ering cells to express the desired components creating bioartificial scaffolds which mimick the natural extracellular matrix and will fulfil the requirements of mechanical support, compartmentalization, storage and sequestration of molecules. This also w ill have correct porosity allowing for diffusion of soluble molecules and access to cells, exposing ligands for adhesion and proliferation and being degradable by enzymatic mechanisms to allow body directed remodelling.

Call for proposal

FP6-2003-NMP-TI-3-MAIN
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

UPPSALA UNIVERSITY
Address
S.t Olofsgatan 10B
Uppsala
Sweden

Participants (7)

HOSPICES CANTONAUX, CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
Address
Rue Du Bugnon 46
Lausanne
INDIAN INSTITUTE OF TECHNOLOGY
India
Address
Hauz Khas
New Delhi
KAROCELL TISSUE ENGINEERING AB
Sweden
Address
Karolinska University Hospital, Forskningscentrum M3:01
Stockholm
RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE AACHEN
Germany
Address
Templergraben 55
Aachen
SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE
Switzerland
Address
Ecublens (J2-506 (Building Ch) Station 6)
Lausanne
THE UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London