Objective The project proposed is therefore a radically new approach to fabricate safe bioactive materials for tissue engineering and regenerative medicine. We propose to use cells as micro-factories to produce and assemble the molecular components at the nanometer level which is not possible by conventional mechanical engineering. This cellular engineering will be used to produce the supportive structure with desired shape, compliance and mechanical strength at meso- and macroscale levels. We achieve this by engine ering cells to express the desired components creating bioartificial scaffolds which mimick the natural extracellular matrix and will fulfil the requirements of mechanical support, compartmentalization, storage and sequestration of molecules. This also w ill have correct porosity allowing for diffusion of soluble molecules and access to cells, exposing ligands for adhesion and proliferation and being degradable by enzymatic mechanisms to allow body directed remodelling. Fields of science medical and health sciencesmedical biotechnologytissue engineeringengineering and technologymechanical engineering Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2003-3.4.2.2-3 - Intelligent' bio-materials for tissue repair and regeneration NMP-2003-3.4.2.2-1 - Materials processing by radically innovative technologies Call for proposal FP6-2003-NMP-TI-3-MAIN See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator UPPSALA UNIVERSITY Address S.t olofsgatan 10b Uppsala Sweden See on map Links Website Opens in new window EU contribution € 0,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all HOSPICES CANTONAUX, CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Switzerland EU contribution € 0,00 Address Rue du bugnon 46 Lausanne See on map Links Website Opens in new window INDIAN INSTITUTE OF TECHNOLOGY India EU contribution € 0,00 Address Hauz khas New delhi See on map Links Website Opens in new window KAROCELL TISSUE ENGINEERING AB Sweden EU contribution € 0,00 Address Karolinska university hospital, forskningscentrum m3:01 Stockholm See on map Links Website Opens in new window RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE AACHEN Germany EU contribution € 0,00 Address Templergraben 55 Aachen See on map Links Website Opens in new window SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE Switzerland EU contribution € 0,00 Address Ecublens (j2-506 (building ch) station 6) Lausanne See on map Links Website Opens in new window THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 0,00 Address Oxford road Manchester See on map Links Website Opens in new window UNIVERSITY COLLEGE LONDON United Kingdom EU contribution € 0,00 Address Gower street London See on map Links Website Opens in new window
