Objective
The development of new polymeric biomaterials designed to stimulate specific cellular responses at the molecular level such as activation of signalling pathways that control gene activity involved in maintenance, growth, and functional regeneration of li ver tissue in vitro could be an important step in tissue engineering. The project is aimed to the development of polymeric synthetic and biodegradable biomaterials to control liver cell responses in vitro and in vivo systems. Isolated hepatocytes are abl e to continue the full range of known in vivo liver specific functions for only a short time. The in vitro maintenance of competent hepatocytes is decidable so that the liver functions can be studied in a controlled environment. Engineered liver tissue c onstructs may provide an inexpensive and reliable in vitro physiological model with great control of variables for studying disease, drug, infection and molecular therapeutics. New modified polyetheretherketone PEEK-WC membranes will be prepared in hollow fiber configurations. Membranes will be prepared by phase inversion technique, which permits to obtain membranes with various structural properties by means of kinetic and thermodynamic parameter control. In addition, the development of synthetic polyme ric materials consisting of nanofiber network scaffolds represents an entirely new approach to tissue engineering that has relied in the past on materials that where either of unknown composition (i.e. Matrigel) or not possible to design (i.e. Collagens ). Thus, the design and preparation of synthetic three-dimensional nanofiber network scaffolds that highly mimic the extracellular matrix will be a valuable tool in the field. The surface of membranes/scaffolds to be utilized in the project will be modif ied by non equilibrium plasma-chemical processes such as Plasma Deposition of thin films (PE-CVD) and Plasma Treatments to adapt their properties to the best compatibility with cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental biotechnology bioremediation bioreactors
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences plasma physics
- medical and health sciences medical biotechnology tissue engineering
- natural sciences physical sciences optics microscopy
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-NMP-TI-3-MAIN
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LEIPZIG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.