Objective
Chronic airway diseases like asthma, chronic bronchitis and cystic fibrosis belong to the most frequent chronic diseases in Europe. Progress in the understanding of the pathophysiology and development of effective treatments for these diseases has been ham pered by the lack of good animal models, i.e. even "knock-out" mice for the monogenic disease cystic fibrosis lacked a lung disease phenotype. We have recently developed a novel transgenic mouse model with airway-specific overexpression of epithelial sodiu m channels (ENaC) and demonstrated that a dysbalance of airway ion transport causes a severe spontaneous lung disease that shares common features with human chronic airway diseases, including mucus obstruction, goblet cell metaplasia and inflammation (Mall M et al, Nat. Med. 2004). The overall goal of this project is to exploit and further develop this animal model for studies on the pathogenesis and the development of novel treatments for chronic airway diseases. We will test the therapeutic in vivo effect s of ion channel modulators, and novel inhibitors of inflammation and mucus hypersecretion. Furthermore, we will identify novel genes that modify disease severity in bENaC overexpressing mice by a microarray approach. Finally, we will establish a novel mou se model with an inducible chronic bronchitis phenotype to circumvent early pulmonary mortality associated with constitutive bENaC overexpression. We will use this regulated model for studies on the role of chronic exposure to allergens and pathogens, and endogenous lung repair mechanisms acting once the bENaC transgene is switched off. The success of this project will build upon the high level of expertise of the team leader and host in the proposed tasks. It will result in the establishment of an interdis ciplinary research team that will significantly contribute to a better understanding of the pathogenesis and development of more effective therapies for chronic airway diseases at a high level of excellence.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- social sciences sociology demography mortality
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-8
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.