Objective
There is a worldwide pent-up demand for the development of new technologies to allow rapid medical diagnostic and specific human therapy. One of the major challenges now is to develop delivery systems, which are convenient and effective for tackling problems in disease treatments. We have developed two new strategies aiming at producing and delivering biotherapeutic proteins.
The first one is based on the use of polypeptide transduction carriers to directly deliver therapeutic proteins into mammalian tissues and cells. We have recently isolated and characterised two new natural polypeptides transduction carriers, which have the capacity with a high efficiency to directly traverse biological membranes. We anticipate that these membrane permeable proteins will represent a new class of transduction carriers and may have important functions in protein therapy for cancer and infectious diseases.
The second one focused on in vitro protein synthesis technologies for producing recombinant proteins. We have recently demonstrated the effectiveness of a cell-free expression system in production of membrane proteins directly coupled to liposomes. Our technology for producing membrane proteins represents an original and powerful approach to produce immunogenic proteoliposomes fo r the development of new vaccines delivery systems and therapeutic proteoliposomes for human diseases.
The long-term objective of this proposal is to provide new vectors for biologically relevant vaccines and delivery of therapeutic proteins and also, to in crease our potential in therapeutic strategies. These biological vectors will be checked for their transduction properties by testing therapeutic protein candidates on human diseases models. This original approach represents a unique system that would allow increasing the potential in therapeutic strategies for the European academic and pharmaceutical laboratories and will bring out a considerable breakthrough into the worldwide human therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer melanoma
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences health sciences public health epidemiology modeling of diseases spread
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-8
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GRENOBLE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.