Objective
Apoptosis is a highly regulated mechanism used by cells to counterbalance the ongoing process of mitosis. Dys-regulation of this delicate balance is involved in many human diseases, and is central to the genesis and progression of cancer. Advancing the research of apoptosis is of critical importance in the development of novel therapies, with over 1.5 million people dying as a result of cancer in Europe and America each year.
While apoptosis holds much promise, the complexity of its biology and lack of translation from bench to clinic has limited its potential thus far. Prof. Tom Cotter, a European leader the apoptosis field, founded EiRx Therapeutics plc. EiRx has established a reputation of cutting edge applied research and has identified circa 200 genes that functionally regulate apoptosis in cancer. To translate these targets to chemical molecules in the clinic would be to unlock the real value from EiRx's research, this requires a world-class Drug Discovery capability.
This proposal describes how EiRx will transfer and integrate specialist industrial Drug Discovery knowledge (not currently found in the host country) with its already world-class apoptosis biology, to take its research all the way to the clinic. Specifically, this requires recruiting a very senior Assay Development and Screening Scientist, a Biochemist, and a Medicinal Chemist over a three-year period. By linking biology with chemistry, this multidisciplinary team will significantly advance European apoptosis research and advance new treatments for cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-3
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CORK
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.