Objective
Lipids are central to the regulation and control of cellular function and to disease and lipidomics is beginning to make significant contributions to understanding cellular and pathophysiological processes. Alkyllysophospholipid analogues have recently received much attention due to their antineoplastic, immunomodulatory and antiparasitic properties. The present proposal aims at developing cost effective, reliable and efficient technologies based on solid phase chemistry (SPOS) for the synthesis of ether phospholipid analogues.
Focused libraries will be synthesised for optimisation of structural features of lead compounds produced at the laboratories of the Institute of Organic and Pharmaceutical Chemistry for specific biological applications including antiprotozoal therapeutics and anticancer compounds. In parallel, SPOS will be used to prepare dendrimeric materials and, particularly, dendrimer-modified resins designed to provide increased loading capacity for solid supports. These modified resins will be evaluated for phospholipid solid phase synthesis.
To complement these activities, the use of High-Energy Techniques with microwaves and ultrasound, whose applicability to SPOS is well-documented, will be investigated. By hosting experienced researchers as well as by interacting with the multidisciplinary expertise of the 3 Partner groups, this project aims for transfer of knowledge in these key areas and techniques in order to maintain the momentum of the research of the Host Institute and improve its competitiveness at national and international level, not only in medicinal chemistry but also in its other activities such as the generation of ligands for homogeneous catalysis and of functional organic materials.
The specific knowledge and advanced skills, to be developed through the course of the ToK project, will benefit both basic research and the potential industrial applications. This approach is not applied by other pharmaceutical chemistry groups in Greece.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences chemical sciences catalysis
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ATHENS
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.