Objective
Cancer is one of the most common diseases. Because it is only diagnosed after serious patient symptoms, earlier detection of cancer and earlier treatment can result in patient benefits and reduction of healthcare costs. The approach to go for an earlier treatment requires diagnosis with more sensitive equipment and new ways of diagnosis. For this the use of proteomics to identify prognostic markers for cancer diagnosis is relevant. This multi-analyte technique offers the potential to utilize not only single markers, but also to base a diagnosis on marker combinations. These act as a statistically "fingerprint" to discriminate between patient groups.
Profiling peptides of bodily fluids by mass spectrometry (MS), followed by data mining for MS patterns indicative of diseases in an early stage is seen as a very promising, cost effective approach with diagnostic potential. Also, the combination of this with diagnostic imaging (DI) is even more interesting; this combination to screen and pre-select patients before using imaging optimises the related costs. This ToK proposal is part of the development and clinical acceptance of mass spectrometric peptide patterns (MSPPs) for diagnostic use. This tool is presently still in a research phase in laboratories. Philips considers this project part of a larger scheme to evaluate, improve, and commercialise MSPP as a tool linked to its imaging technologies (both diagnostic and animal imaging).
The areas of proteomics, biomedical and clinical chemical knowledge as well as the dev. of a molecular diagnostic platform require researchers with different background and practical medical experience. Currently, Philips has no access to such background or the experience for medical trials. This proposal aims at getting access to this knowledge by hosting two researchers. We plan to combine MSPP-related know-how then available within the MC project with materials, technologies, and procedures available at Philips Research Aachen.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences computer and information sciences data science data mining
- natural sciences chemical sciences analytical chemistry mass spectrometry
- engineering and technology medical engineering diagnostic imaging
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-3
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
AACHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.