Objective
Epilepsy is an enormous health problem in the E.U. affecting 1-3% of the population. Improved treatment of epilepsy and prolonged single seizures (status epilepticus) would be achieved by targeting the causes of epilepsy and the consequences of seizures. Termed FARMINDE (FAs Receptor Mediates seizure Induced Neuronal Death and Epileptogenesis) this proposal uses a novel transgenic mouse model to investigate a novel cell-signalling pathway in seizure-damaged and epileptic brain. The project will examine how this death receptor influences neuronal loss after seizures and epileptogenesis.
This Marie Curie International Reintegration Grants application is from a researcher who has been an NIH-funded investigator in the USA for the past five years. Work during this time using both in-house developed seizure models and human material challenges prevailing views on the molecular determinants of seizure-induced neuronal death and epilepsy, and offers new directions for treatment. The Researcher has a proven record of translational research with high-impact papers co-authored with clinicians on the subject of epileptic brain injury; skills and training in a bench-to-bedside approach that is a deficit in European research and which can now be brought to the Royal College of Surgeons in Ireland (RCSI, Host).
The RCSI has evolved as the leading Irish institution in state-of-the-art proteomics, resources incorporated into this proposal. RCSI has likewise built a critical mass of experts in the study of the pathogenesis of brain injury, setting the stage for a world-leading team at RCSI in this field. Thus the Researcher can develop their programme of translational epilepsy research, learn new skills through RCSI technology strengths and provide training in bench-to-bedside approaches that increase European scientific competitiveness and fit with the profile of investigators that are to be attracted back to the E.U. via the IRG mechanism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- natural sciences biological sciences cell biology cell signaling
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.