Objective
The proposed research concerns molecular beacon technology in infectious diseases in general and HIV disease in particular. This is a well-timed area with numerous possible applications and where fundamental technologies in biomedical sciences are limiting and novel technologies are increasingly in demand.
The first overall goal of this initial research project is to investigate the role of HIV-1 cellular viral load and antiretroviral drug-resistant variants on the antiretroviral treatment of HIV-1-infected individuals by using novel quantitative HIV-1 diagnostic assays. The assays have been previously constructed and evaluated in our laboratory and are based on molecular beacon and allele discriminating real-time PCR technologies that is the primary technology of our laboratory.
Our first aim involves investigating the implications of the concentration of HIV-1 DNA in peripheral blood mononuclear cell PBMC) samples ('HIV-1 cellular Viral Load') in predicting the virological response to antiretroviral therapy. In the second aim, we will quantify minor populations of HIV-1 drug resistant strains on mother-to-infant HIV-1 cohorts.
The results of the proposed studies will have a direct impact on the clinical care of HIV-1-infected individuals including Cypriot patients. The second goal is to investigate the phylogenic (subtype) distribution and spread of antiretroviral drug-resistance of HIV-1 strains from recent and long-standing patients in Cyprus.
It is hoped that the grant support of the Marie Curie International Reintegration Grant will allow the principal investigator to establish a new research laboratory in the University of Cyprus in the best possible conditions and initiate my research activities.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health epidemiology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine medical genetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
20537 NICOSIA
Cyprus
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.